Lancet:蚊唾液疫苗耐受性及免疫原性研究

2020-06-26 MedSci原创 MedSci原创

冈比亚按蚊唾液疫苗耐受性及免疫原性良好

在动物模型中,对蚊子唾液蛋白免疫可保护动物模型免受蚊子传播疾病的影响。 近日研究人员评估了冈比亚按蚊唾液疫苗(AGS-v)的安全性和免疫原性。
 
本次研究为I期临床研究,在美国开展,18-50岁的无蚊虫叮咬严重过敏反应史患者参与研究,随机接受200mmol AGS-v疫苗,含Montanide ISA 51佐剂的200mmol AGS-v疫苗以及无菌水对照。在第0和21天接受注射,随后暴露于冈比亚按蚊环境中42天。研究的主要终点为安全性和免疫原性。
 
49名志愿者参与研究,其中17人接受含佐剂疫苗,16人接受疫苗,16人为对照。研究中未发生系统性安全事件,但1名接受含佐剂疫苗志愿者发生3级红斑皮疹。含佐剂疫苗组疼痛、肿胀、红斑和瘙痒等局部症状发生率高于其他两组。42天,含佐剂疫苗组疫苗特异性总IgG抗体增加幅度显著高于其他2组,同时外周血单个核细胞产生IFN-γ量显著增加,而其他2组IFN-γ量未见显著增加。
 
研究认为,冈比亚按蚊唾液疫苗耐受性及免疫原性良好。
 
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    2021-02-08 howi
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    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

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    2020-06-26 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0