新研究显示BCL2抑制剂联合CD20单抗治疗慢性淋巴细胞白血病,缓解率达95%

2019-04-17 不详 MedSci原创

这项研究由莱斯特大学的研究人员,在来自11个地区的120名参与者中完成。接受venetoclax(BCL2的口服抑制剂)和obinutuzumab(静脉注射CD20单克隆抗体)组合治疗的患者,高达95%具有完全缓解率,血液或扫描中均没有观察到白血病的迹象,并且患者也没有疾病症状。

全球研究的结果表明,慢性淋巴细胞白血病(CLL)患者将来可能会接受无化疗治疗。

这项研究由莱斯特大学的研究人员,在来自11个地区的120名参与者中完成。接受venetoclax(BCL2的口服抑制剂)和obinutuzumab(静脉注射CD20单克隆抗体)组合治疗的患者,高达95%具有完全缓解率,血液或扫描中均没有观察到白血病的迹象,并且患者也没有疾病症状。

英国癌症研究中心临床试验研究员兼莱斯特大学副教授哈里特沃克博士说:"化疗目前是CLL患者的一线治疗方法。然而化疗并不适合于老年或有其他健康问题的患者。此外,有些患者会进展为对化疗有抵抗力的CLL。我们希望venetoclax和obinutuzumab的组合可以成为一种新的治疗选择,从而更有效地治疗CLL患者。"

CLL是由于骨髓产生过多的淋巴细胞,占据了骨髓中太多的空间,因此没有足够的空间来制造正常的红细胞和血小板。CLL是成人慢性白血病的最常见形式。

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    2019-09-04 jklm09
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    2020-03-10 aliceclz
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    2020-01-22 liuquan
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    2019-04-27 清风拂面

    谢谢分享学习

    0

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    2019-04-19 Boyinsh
  7. [GetPortalCommentsPageByObjectIdResponse(id=1851966, encodeId=b6111851966d5, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Wed Sep 04 00:58:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943790, encodeId=61e61943e9096, content=<a href='/topic/show?id=44ca428e60' target=_blank style='color:#2F92EE;'>#CD20#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4287, encryptionId=44ca428e60, topicName=CD20)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Tue Mar 10 21:58:00 CST 2020, time=2020-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995558, encodeId=0243199555852, content=<a href='/topic/show?id=992411149e' target=_blank style='color:#2F92EE;'>#2抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1114, encryptionId=992411149e, topicName=2抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28b7142, createdName=liuquan, createdTime=Wed Jan 22 09:58:00 CST 2020, time=2020-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365353, encodeId=8a09365353a8, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Apr 27 09:18:54 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302242, encodeId=ccfd1302242db, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Fri Apr 19 10:58:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446593, encodeId=aa8b144659339, content=<a href='/topic/show?id=1f8a326e6f' target=_blank style='color:#2F92EE;'>#BCL2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3267, encryptionId=1f8a326e6f, topicName=BCL2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fdbf5248081, createdName=Boyinsh, createdTime=Fri Apr 19 10:58:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581384, encodeId=2fca158138448, content=<a href='/topic/show?id=29e042919d' target=_blank style='color:#2F92EE;'>#CD20单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4291, encryptionId=29e042919d, topicName=CD20单抗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f716785352, createdName=ms8888626721583891, createdTime=Fri Apr 19 10:58:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364846, encodeId=70db36484662, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Apr 18 16:37:24 CST 2019, time=2019-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997940, encodeId=038e199e9409f, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Sun Nov 17 19:58:00 CST 2019, time=2019-11-17, status=1, ipAttribution=)]
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    2019-04-18 清风拂面

    谢谢分享学习

    0

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BTK抑制剂伊布替尼(IBR)已被批准用于慢性淋巴细胞白血病(CLL)的治疗。BCL2抑制剂Venetoclax(VEN),被批准用于接受过治疗并伴17p- CLL患者的治疗。IBR与VEN联合用药的原理包括如下几个方面:1)预试验显示IBR与VEN具有协同作用;2)两药联用不导致毒性增加;3)两药具有不同的作用机制;4)两药在疾病治疗方面具有互补效应。在此对IBR与VEN联用治疗CLL的二期