J Allergy Clin Immunol:金黄色葡萄球菌定植与食物过敏有关

2020-06-28 MedSci原创 MedSci原创

金黄色葡萄球菌与湿疹,过敏性鼻炎,哮喘和食物过敏的病理生理学有关。金黄色葡萄球菌是更严重的湿疹的标志,湿疹是食物致敏/过敏的危险因素。因此,湿疹患者的金黄色葡萄球菌与食物过敏之间的关联可能与湿疹的严重

金黄色葡萄球菌与湿疹,过敏性鼻炎,哮喘和食物过敏的病理生理学有关。金黄色葡萄球菌是更严重的湿疹的标志,湿疹是食物致敏/过敏的危险因素。因此,湿疹患者的金黄色葡萄球菌与食物过敏之间的关联可能与湿疹的严重程度有关。

 

我们试图调查金黄色葡萄球菌定植与特定IgE(sIgE)的产生与婴儿湿疹严重程度无关的常见食物过敏原和儿童早期过敏的关联。此外,我们还确定了金黄色葡萄球菌定植与湿疹严重程度和持续性的关系。

 

在“早期学习花生过敏”(LEAP)研究中,研究人员评估了参与者的湿疹严重程度,并对皮肤/鼻拭子培养了金黄色葡萄球菌。通过测量sIgE水平来识别过敏。主要通过口服食物刺激确定,而持久性鸡蛋过敏主要通过皮肤点刺试验确定花生过敏。

 

结果显示,在整个LEAP研究中,金黄色葡萄球菌定植与湿疹严重程度显着相关,而在12和60个月大时,它与随后的湿疹恶化有关。在任何时间点皮肤金黄色葡萄球菌定植均与鸡蛋蛋白和花生sIgE水平升高有关,而与湿疹严重程度无关。金黄色葡萄球菌的参与者在60和72个月大时更容易出现持续的鸡蛋过敏和花生过敏,而与湿疹严重程度无关。9 LEAP研究中存在花生过敏症(9/312)的消费者中,除一名消费者外,其他人至少都接受过一次金黄色葡萄球菌定植。

 

综上所述,该研究结果表面,金黄色葡萄球菌与湿疹的严重程度无关,与食物过敏和过敏有关,并可能削弱对食物的耐受性。这可能是将来旨在诱导和维持湿疹婴儿食物过敏原耐受性的干预措施中的重要考虑因素。

 

原始出处:

 

Olympia Tsilochristou , George du Toit, et al., Association of Staphylococcus Aureus Colonization With Food Allergy Occurs Independently of Eczema Severity. J Allergy Clin Immunol. 2019 Aug;144(2):494-503. doi: 10.1016/j.jaci.2019.04.025.

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    2020-06-30 膀胱癌
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    2020-06-30 yhy100201
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