Br J Cancer:体重指数(BMI)和**淋巴细胞计数(ALC):乳腺癌患者无病生存期的预测指标

2021-04-30 xiaozeng MedSci原创

在最近的几十年里,全球乳腺癌患病率正逐年升高,其作为女性中最常见的恶性肿瘤之一,在韩国2016年共有2000多例死亡病例。

在最近的几十年里,全球乳腺癌患病率正逐年升高,其作为女性中最常见的恶性肿瘤之一,在韩国2016年共有2000多例死亡病例。

由于乳腺癌是一种具有多种生物学特征的异质性疾病,激素受体、HER2(人表皮生长因子受体2)、疾病的阶段以及Ki-67标记物指数(LI)等因素均会影响患者的预后。


肥胖作为受全球关注的另一个主要健康问题。在韩国,超过60%的40岁以上女性超重或肥胖。肥胖作为糖尿病血管疾病和肾脏疾病的一大危险因素,虽然激素水平、脂肪细胞因子和炎性细胞因子已被揭示为其潜在的介质,但肥胖与乳腺癌患者存活率之间的关系仍有待研究。

该研究旨在评估乳腺癌患者和健康女性的体重指数(BMI)和绝对淋巴细胞计数(ALC)之间的关联性,并确定了这些因素在乳腺癌中的预后价值。

在该研究中,研究人员通过分析1225例原发性浸润性乳腺癌患者和35991例健康女性参与者,采用多变量Cox风险比例模型评估了包括患者的BMI指数和无病生存期(DFS)相关的全血细胞计数在内的多种因素。

根据BMI比较ALC的箱形图

结果显示,乳腺癌患者和健康女性的BMI和ALC呈正相关。在多变量分析中,相比于体重过轻或正常的个体,超重或肥胖的参与者的DFS较差,而高ALC的患者的DFS优于低ALC患者。

根据BMI/ALC数据进行风险分层后,研究人员发现,相比于其他患者,BMI高/ALC低的高风险患者的DFS更差。

Kaplan-Meier生存曲线分析

总而言之,该研究结果显示,参与者BMI指数和ALC呈正相关,但对乳腺癌患者的预后影响则是相反的。BMI高/ALC低的患者的DFS较其他患者更差。该研究也建议进一步的研究BMI/ALC影响乳腺癌患者预后的潜在机制。

原始出处:

Ko, S.M., Lee, J., Bae, S.J. et al. Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients. Br J Cancer (19 April 2021).

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    2021-05-14 ms7000000414344418

    长胖了哪儿都不对

    0

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    2021-05-02 ms2000001361349190

    BMI高/ALC低的患者的DFS较其他患者更差

    0

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