Circulation:普通人群亚临床动脉粥样硬化的发生率

2021-09-21 Nebula MedSci原创

CCTA 检查到的动脉粥样硬化的发生率随着 CAC 评分的增加而增加,即使 CAC 评分为 0 的个体,也有 5.5% 的存在动脉粥样硬化,0.4% 的存在明显狭窄

除了冠状动脉钙化 (CAC) 评分外,使用冠状动脉计算机断层扫描血管造影 (CCTA) 及早发现冠状动脉粥样硬化可能有助于制定预防策略。Persson等研究人员使用 CCTA 来确定一般人群中冠状动脉粥样硬化的患病率、严重程度和特征及其与 CAC 评分的关联。 研究人员招募了 30154 位随机邀请的 50-64 岁的成年人进入 SCAPIS 研究。该研究纳入了既往无已知冠状动脉疾病(如心肌梗死或心脏手术)、有高质量 CCTA 和 CAC 结果的个体。根据非对比图像进行 CAC 评分。目视读取 CCTA 图像并对每段冠状动脉硬化进行评分(无动脉硬化、1%-49%狭窄、≥50%狭窄)。 CCTA 检查到的动脉粥样硬化的患病率 总体上,共纳入了 25182 位无已知冠状动脉心脏病的个体(50.6%的女性)。在 42.1% 的个体中发现了任何 CCTA 检查出的动脉硬化;5.2% 的个体存在任何显著狭窄(≥50%);1.9% 的个体存在左主干、左前降支近端或 3 支血管病变;该人群 8.3% 的个体存在任何非钙化斑块。女性发生动脉粥样硬化的年龄平均延迟了 10 年。动脉粥样硬化在老年人中更为

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    2021-09-21 病毒猎手

    #亚临床##动脉粥样硬化#,这样的研究应该值得大家关注,现在医学要关注很多疾病的亚临床状况!

    0

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近期,FOURIER试验(高风险患者应用PCSK9抑制剂的远期心血管预后研究)显示PCSK9抑制剂evolocumab可显著减少稳定型动脉粥样硬化血管疾病患者(包括既往发生过心肌梗死[MI]的患者)的主血管事件。研究人员推测在大量的有心肌梗死病史的患者中可能存在可鉴别应用evolocumab临床风险降低较明显的患者亚群的特征。研究人员根据最后一次心梗的时间、既往心梗的次数和是否存在多支参与冠脉病变