JACC:心衰伴二尖瓣返流患者健康状态的变化与预后的相关性研究

2020-04-28 MedSci原创 MedSci原创

在COAPT临床试验中,经导管二尖瓣修补术(TMVr)结合二尖瓣成形术(MitraClip)可迅速改善心衰合并严重继发性二尖瓣返流患者的健康状况,降低长期死亡和心力衰竭(HF)的风险。本研究的目的是探

在COAPT临床试验中,经导管二尖瓣修补术(TMVr)结合二尖瓣成形术(MitraClip)可迅速改善心衰合并严重继发性二尖瓣返流患者的健康状况,降低长期死亡和心力衰竭(HF)的风险。本研究的目的是探究COAPT人群早期健康状况的变化是否与长期临床结果相关。

在551名心衰合并严重继发性二尖瓣返流患者中,从基线检查到1个月,那些随机接受TMVr治疗的患者比单独接受指南指导下药物治疗(GDMT)的患者更有可能在健康状态方面获得≥10分的改善。健康状态的早期改善与1个月至2年内死亡或心衰住院风险呈负相关(p<0.001)。在对人口统计学和临床因素进行调整后,患者健康状态的变化与预后的相关性增强(危险比:0.79;95%可信区间:0.73-0.86;p<0.001)。

研究结果显示,在心衰合并严重继发性二尖瓣返流患者中,特定疾病健康状况的短期变化与随后的长期死亡或心衰住院风险密切相关。

原始出处:

Suzanne V et al.Health Status Changes and Outcomes in Patients With Heart Failure and Mitral Regurgitation.JACC.2020 Apr.

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    2020-09-16 hbwxf
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1854757, encodeId=c9c31854e57e2, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Sep 16 23:14:37 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837822, encodeId=e5cb183e822bb, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Dec 08 06:14:37 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326602, encodeId=c2ae132660211, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Apr 30 04:14:37 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418762, encodeId=50a51418e62d6, content=<a href='/topic/show?id=e5be23919cf' target=_blank style='color:#2F92EE;'>#二尖瓣返流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23919, encryptionId=e5be23919cf, topicName=二尖瓣返流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad623409629, createdName=kksonne, createdTime=Thu Apr 30 04:14:37 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463284, encodeId=0094146328495, content=<a href='/topic/show?id=cff92389310' target=_blank style='color:#2F92EE;'>#二尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23893, encryptionId=cff92389310, topicName=二尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fdb26536308, createdName=wwzzly, createdTime=Thu Apr 30 04:14:37 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382289, encodeId=ca523822891b, content=非常非常好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Tue Apr 28 14:04:36 CST 2020, time=2020-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382288, encodeId=0ffd38228855, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200622/2690090c15ff4d0181b6c45ca2ffd1e2/9f00b8c9ed6c460eb8ed3e3500194f3d.jpg, createdBy=10652049728, createdName=阿菡, createdTime=Tue Apr 28 14:04:20 CST 2020, time=2020-04-28, status=1, ipAttribution=)]
    2020-04-30 wwzzly
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    2020-04-28 阿菡

    非常非常好的文章

    0

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    2020-04-28 阿菡

    好文章

    0

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