Int J Oral Surg:口腔鳞状细胞癌Ib水平的决定因素及其对颌下腺保留的影响

2018-11-24 MedSci MedSci原创

口腔鳞状细胞癌(OSCC)的传统颈清包括切除下颌下腺。一些研究指出,肿瘤直接侵袭腺体的发生率低,并建议保留腺体颈清。

口腔鳞状细胞癌(OSCC)的传统颈清包括切除下颌下腺。一些研究指出,肿瘤直接侵袭腺体的发生率低,并建议保留腺体颈清。

本研究对口腔鳞状细胞癌(OSCC)的Ib水平进行了详细的检查,以评估保留颌下腺在颈清扫术中的可行性,以评估颈下切除术中下颌下腺保留的可行性;探讨原发肿瘤的直接受累率、腺体周围Ib结节的受累情况及其决定因素。

纳入2005年至2014年期间,在研究机构进行手术的口腔,舌头和颊侧原发的586个颈清标本,评估其直接侵袭腺体和周围淋巴结病变。 226例淋巴结阳性患者中,21例(9.3%)肿瘤直接侵袭腺体。危险因素是肿瘤直径> 4 cm(P = 0.002),浸润深度> 10 mm(P = 0.003)。腺周淋巴结病的决定因素是浸润深度> 10 mm(P <0.001),神经周围浸润(P = 0.02),淋巴血管侵犯(P = 0.014)和中/低度分化(P <0.0001)。保留腺体的颈部清扫术在早期肿瘤中是安全的(pT1pN0-1),很有可能在没有放疗的情况下减少口干症。较大的肿瘤,没有明确的证据显示颌下腺浸润或可疑的Ib淋巴结肿大可考虑用于腺体保留,但肿瘤学安全性尚不清楚。

原始出处:

N. Subramaniam,et al.Determinants of level Ib involvement in oral squamous cell carcinoma and implications for submandibular gland-sparing neck dissection.International Journal of  Oral and Maxillofacial Surgery.2018 Decemember. Doi:10.1016/j.ijom.2017.11.019

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    2019-09-05 小几洁
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