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Adv Healthc Mater：新型原位免疫刺激策略可协同增强PDT的效果

2019-11-25 不详 网络

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光动力疗法（PDT）通常会加重肿瘤缺氧，从而促进残留癌细胞的存活和转移。此外，尽管PDT诱导的癌细胞的免疫原性死亡可以诱导宿主抗肿瘤反应，但这种反应通常较弱并且不足以消除残留的癌细胞。本研究中，研究人员设计了基于金属有机框架（MOF）的纳米颗粒，将PDT，抗氧信号转导和CpG佐剂结合起来作为原位肿瘤疫苗，以增强PDT后的宿主抗癌反应。基于MOF的纳米粒子是由H2 TCPP和锆离子自组装而成，表面具

光动力疗法（PDT）通常会加重肿瘤缺氧，从而促进残留癌细胞的存活和转移。此外，尽管PDT诱导的癌细胞的免疫原性死亡可以诱导宿主抗肿瘤反应，但这种反应通常较弱并且不足以消除残留的癌细胞。

本研究中，研究人员设计了基于金属有机框架（MOF）的纳米颗粒，将PDT，抗氧信号转导和CpG佐剂结合起来作为原位肿瘤疫苗，以增强PDT后的宿主抗癌反应。基于MOF的纳米粒子是由H2 TCPP和锆离子自组装而成，表面具有缺氧诱导因子（HIF）信号抑制剂（ACF）和免疫佐剂（CpG），并有透明质酸（HA）涂层。最终的纳米粒子（PCN-ACF-CpG @ HA）可以通过HA特异性靶向过表达CD44受体的癌细胞；ACF可以阻止PDT后加重的低氧生存信号，从而抑制HIF-1α诱导的癌细胞存活和转移。借助CpG佐剂，基于PDT的癌细胞破坏产生的与肿瘤相关的抗原可以启动强大的抗肿瘤免疫反应，从而消除残留的癌细胞。

综上所述，该研究设计了一种新颖的原位免疫刺激策略，可通过在体外和体内激活宿主抗肿瘤免疫应答来协同增强PDT的治疗效果，这在将来可能具有很大的临床转化潜力。

原始出处：

Cai Z, Xin F, et al., Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal-Organic Framework Nanoparticles to Boost Cancer Immunotherapy. Adv Healthc Mater. 2019 Nov 20:e1900996. doi: 10.1002/adhm.201900996.

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    2020-04-14 shizhenshan

    #ALT#

    0

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    2020-05-30 江川靖瑶

    #PDT#

    0

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    2019-11-27 yyanpro@28cn.c

    #Health#

    0

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    2019-11-25 CHANGE

    疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

    0