Front Microbiol:双重作用助力严重感染皮肤损伤的愈合

2019-09-10 不详 网络

抗菌素耐药性正在成为全球最严重的健康威胁之一,因为它不仅妨碍了使用现有抗生素有效治疗传染病,还增加了手术、移植、骨骼和牙齿植入、化疗或慢性伤口处理等医疗程序的感染风险。到目前为止,还没有有效的措施来解决由多重耐药细菌引起的危及生命的医院感染,其中所谓的“ESKAPE”病原体中的革兰氏阴性菌是最令人担忧的。许多此类细菌经常从严重感​​染的皮肤病变中分离出来,例如糖尿病足溃疡(DFU)。本研究中,我们

抗菌素耐药性正在成为全球最严重的健康威胁之一,因为它不仅妨碍了使用现有抗生素有效治疗传染病,还增加了手术、移植、骨骼和牙齿植入、化疗或慢性伤口处理等医疗程序的感染风险。到目前为止,还没有有效的措施来解决由多重耐药细菌引起的危及生命的医院感染,其中所谓的“ESKAPE”病原体中的革兰氏阴性菌是最令人担忧的。许多此类细菌经常从严重感​​染的皮肤病变中分离出来,例如糖尿病足溃疡(DFU)。


本研究中,我们正在寻求包含抗微生物和胶原蛋白诱导图案的新肽构建体,通过发挥双重作用来解决皮肤和软组织感染:抗微生物保护和加快伤口愈合。检测显示,所制备的肽3.1-PP4分别对大肠杆菌和铜绿假单胞菌具有低至1.0和2.1μM的MIC值,并且对HFF-1人成纤维细胞的毒性低。值得注意的是,该肽还对肺炎克雷伯菌,大肠杆菌和铜绿假单胞菌的多药耐药菌株(MIC值在0.5和4.1μM之间)有效,并且阻碍了抗性临床分离株的/解聚的肺炎克雷伯氏菌生物膜的形成。此外,这种值得注意的杂合肽保留了参考药妆肽C16-PP4(“Matrixyl”)的胶原生成诱导行为。

 总之,3.1-PP4对于严重感染皮肤损伤的局部治疗的发展是非常有希望的。

原始出处:

Gomes A, Bessa LJ, et al., Turning a Collagenesis-Inducing Peptide Into a Potent Antibacterial and Antibiofilm Agent Against Multidrug-Resistant Gram-Negative Bacteria. Front Microbiol. 2019 Aug 20;10:1915. doi: 10.3389/fmicb.2019.01915. eCollection 2019.

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    2020-03-06 xjy02
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    2020-01-17 sunylz
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