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Neurology：临床孤立综合征患者血清神经丝的预后价值

2019-01-12 xing.T MedSci原创

CIS血清神经丝预后价值
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由此可见，血清NfL对CIS患者转为MS具有预后价值。NfL可能在MS中扮演生物标志物的双重角色，即峰值水平可以作为严重炎症活动的定量标志物，而稳态水平可以反映神经变性和慢性炎症过程。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员评估血清神经丝轻链（NfL）在临床孤立综合征（CIS）患者中对临床确定的多发性硬化症（CDMS）和McDonald 2017多发性硬化症（MS）的预后作用。

研究人员回顾性地分析了2000年至2015年间神经科入院患者首次脱髓鞘事件的数据。除CSF、MRI和临床数据外，研究人员还评估了基线血清NfL。

222例患者被招募入组（平均随访100.6个月），45例患者（20％）发生CDMS，141例患者（63.5％）2年内发生2017MS。最近复发的患者血清NfL（中位数为22.0，四分位数范围为11.6-40.4 pg/mL）显著增加，在基线MRI时有大量T2和钆增强病变。血清NfL是CDMS和McDonald 2017 MS患者的预后因素，在低水平和极低水平的NfL患者中CDMS和2017 MS风险分别降低三倍和两倍。在调整诸如寡克隆带、Gd增强病变和基线MRI上的高T2病变负荷之类的已知的MS预后因素之后，结果保持不变。NfL与基线时的残疾有关，但与随访无关。

由此可见，血清NfL对CIS患者转为MS具有预后价值。NfL可能在MS中扮演生物标志物的双重角色，即峰值水平可以作为严重炎症活动的定量标志物，而稳态水平可以反映神经变性和慢性炎症过程。

原始出处：

Gloria Dalla Costa,et al.Prognostic value of serum neurofilaments in patients with clinically isolated syndromes.Neurology. 2019.http://n.neurology.org/content/early/2019/01/11/WNL.0000000000006902

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    2019-04-28 lizhou0204

    #神经丝#

    0

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    2019-03-24 yinhl1978

    #Neurol#

    0

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    2019-01-16 wxl882001

    了解一下

    0

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    2019-01-16 wxl882001

    学习一下

    0

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    2019-01-14 paperyu

    #预后价值#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1801658, encodeId=a198180165822, content=<a href='/topic/show?id=91f1e4142bd' target=_blank style='color:#2F92EE;'>#神经丝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74142, encryptionId=91f1e4142bd, topicName=神经丝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Sun Apr 28 05:06:00 CST 2019, time=2019-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000679, encodeId=92ab20006e9d6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Mar 24 14:06:00 CST 2019, time=2019-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358367, encodeId=88ca35836eee, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Wed Jan 16 19:55:44 CST 2019, time=2019-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358366, encodeId=250f358366ac, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Wed Jan 16 19:54:22 CST 2019, time=2019-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385221, encodeId=e39713852210d, content=<a href='/topic/show?id=dc121001e22d' target=_blank style='color:#2F92EE;'>#预后价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100172, encryptionId=dc121001e22d, topicName=预后价值)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Mon Jan 14 04:06:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431412, encodeId=d8291431412e4, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 04:06:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357917, encodeId=1bde35e91719, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jan 12 14:29:29 CST 2019, time=2019-01-12, status=1, ipAttribution=)]
    2019-01-14 zhouqu_8

    #综合征#

    0

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    2019-01-12 龙胆草

    学习谢谢分享

    0