J Endod:氯己定和次氯酸钠在根管去感染中的抗微生物作用:一项系统性综述和meta分析

2020-06-02 lishiting MedSci原创

这篇研究的目的是为了比较氯己定(CHX)和次氯酸钠(NaOCl)这2种恒牙根管治疗过程中常用冲洗液抗微生物的作用。

这篇研究的目的是为了比较氯己定(CHX)和次氯酸钠(NaOCl)这2种恒牙根管治疗过程中常用冲洗液抗微生物的作用。

研究搜寻了PubMed, EMBASE, Web of Science和Cochrane Library电子数据库在2020年3月之前的随机对照试验。采用随机效应模型及95%置信区间(CI)实施meta分析以评估相对风险度(RR)和标准化均数差(SMD)。采用细菌检测的培养和分子学方法进行亚组分析。

结果显示,文献搜索共得到2,110个记录,无重复项。8篇文章符合系统性文献回顾。冲洗后,阳性细菌生长样本的发生率之间未见显著性差异(RR=1.003, 95% CI: 0.729-1.380, p=0.987),并且在培养和分子学方法亚组的CHX和NaOCl之间可见平均细菌数量的变化(SMD=0.311, 95% CI: -0.368-0.991, p=0.369)。各研究间的异质性RR (I2=0%, p=0.673)较低,而在SMD的分析中存在显著的异质性(I2=76.336%, p=0.005)。

结论:研究表明,CHX和NaOCl冲洗后可减弱细菌感染,但是2者之间的抗菌效果没有显著性差异。尽管CHX和NaOCl表现出相似的效果,但是它们的分子机制并不相同。因此,它们可以被用做主要的抗菌根管冲洗液。然而,研究受到检索文章存在不一致的限制,并且缺少临床相关疗效。为此,还需要更多设计合理的临床研究进一步确定此项研究的结果。

原始出处:

Kasidid Ruksakiet, Lilla Hanák, et al. Antimicrobial Efficacy of Chlorhexidine and Sodium Hypochlorite in Root Canal Disinfection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Endod., 2020 May 12;S0099-2399(20)30308-3. doi: 10.1016/j.joen.2020.05.002.

 

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    2020-08-11 一闲
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level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64095, encryptionId=37286409571, topicName=氯己定)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5V6pBDhhleaA9ZQaNgImyx09qqFom6WIvSGdUoWfKiaWCiaeUfnXMRECAMPA81Wkd4EOicrPibOTudQ/132, createdBy=b9382500209, createdName=ms6127405442416114, createdTime=Thu Jun 04 11:26:15 CST 2020, time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523030, encodeId=06591523030b6, content=<a href='/topic/show?id=c72462241ff' target=_blank style='color:#2F92EE;'>#根管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62241, encryptionId=c72462241ff, topicName=根管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba5e11492705, createdName=zhaozhouchifen, createdTime=Thu Jun 04 11:26:15 CST 2020, time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529323, encodeId=2fbd152932377, content=<a href='/topic/show?id=cf226303999' target=_blank style='color:#2F92EE;'>#次氯酸钠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63039, encryptionId=cf226303999, topicName=次氯酸钠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adbb11925025, createdName=millore, createdTime=Thu Jun 04 11:26:15 CST 2020, time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601211, encodeId=cde260121121, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Jun 02 21:38:00 CST 2020, time=2020-06-02, status=1, ipAttribution=)]
    2020-12-16 guojianrong
  5. 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  6. 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  7. 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time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529323, encodeId=2fbd152932377, content=<a href='/topic/show?id=cf226303999' target=_blank style='color:#2F92EE;'>#次氯酸钠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63039, encryptionId=cf226303999, topicName=次氯酸钠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adbb11925025, createdName=millore, createdTime=Thu Jun 04 11:26:15 CST 2020, time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601211, encodeId=cde260121121, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  8. 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  9. 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time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529323, encodeId=2fbd152932377, content=<a href='/topic/show?id=cf226303999' target=_blank style='color:#2F92EE;'>#次氯酸钠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63039, encryptionId=cf226303999, topicName=次氯酸钠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adbb11925025, createdName=millore, createdTime=Thu Jun 04 11:26:15 CST 2020, time=2020-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601211, encodeId=cde260121121, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2020-06-02 wxl882001

    了解一下

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