JCEM:母体总胆固醇水平与小于孕龄儿或大于孕龄儿的关联

2021-08-21 MedSci原创 MedSci原创

孕中期母体TC水平与SGA或LGA相关。孕中期母体TC可能有助于预测SGA和LGA。

母体胆固醇对胎儿发育很重要。妊娠中期母体血清总胆固醇(母体TC)水平是否与小于孕龄儿(SGA)或大于孕龄儿(LGA)相关尚无定论。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在前瞻性探究妊娠中期母体TC与SGA或LGA之间的关联。


日本环境与儿童研究是日本一项全国性的前瞻性出生队列研究。参与者共有37449名非糖尿病、非高血压的足月单胎母亲。该研究的结局指标出生体重<10%和≥90%百分位数分别定义SGA和LGA。


孕妇采血时的平均胎龄为22.7±4.0周。在调整了母亲的年龄、孩子的性别、胎次、孕期体重增加、孕前BMI、吸烟、饮酒、血糖水平、家庭收入和研究地区后,母体TC降低一个标准差与SGA线性相关[比值比(OR):95%置信区间(CI)=1.20:1.15-1.25]。相比之下,母体TC每增加一个标准差与LGA线性相关[OR:95%CI=1.13:1.09-1.16]。根据孕前BMI和孕期体重增加,相关性没有差异(交互作用p>0.20)。
 
由此可见,孕中期母体TC水平与SGA或LGA相关。孕中期母体TC可能有助于预测SGA和LGA。

原始出处:

Kayo Kaneko.et al.Association of maternal total cholesterol with SGA or LGA birth at term: The Japan Environment and Children's Study.JCEM.2021.https://doi.org/10.1210/clinem/dgab618

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    2022-07-13 仁者大医
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    2021-09-25 achengzhao
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