Br J Gen Pract:血小板计数高——癌症的强有力预测指标!

2017-05-23 sunshine2015 来宝网

根据大规模的研究,高血小板计数是癌症的强大预测因子,应该紧急调查挽救生命。 在英国,40至50万人中约有2%的人血小板计数升高,称为血小板增多症

根据大规模的研究,高血小板计数是癌症的强大预测因子,应该紧急调查挽救生命。

在英国,40至50万人中约有2%的人血小板计数升高,称为血小板增多症。

现在,由埃克塞特大学医学院领导的40,000例患者记录的研究发现,超过11%的男性和6%的40岁以上的血小板增多患者在一年内被诊断患有癌症。如果在六个月内记录第二次升高的血小板计数,被诊断癌症的数字上升为18%的男性和10%的女性。

在一般人群中,约1%在任何一年发展为癌症。在分析的队列中,由GP接受血液检查的人群中,约有4%的男性和2%的妇女患有癌症。肺和结肠直肠癌更常经血小板增多症被诊断。三分之一的血小板增多症患者和肺或结肠直肠癌患者没有其他症状能表明他们患有癌症。

这篇论文发表在英国“一般实践杂志”上,呼吁全科医生考虑在出现意想不到的血小板增多症的患者中诊断癌症,以增加可以挽救生命的早期诊断。

埃克塞特大学医学院的主要作者Sarah Bailey博士说:“我们知道,早期诊断对于人们是否能够生存下去是至关重要的。我们的研究表明,相当多的人可能会在三个月前诊断癌症,如果血小板增多症促使癌症进行调查,这可能对早期诊断有重要的意义。”

该研究使用英国临床实践研究数据链(UK Clinical Practice Research Datalink)的数据进行,其中包括来自英国8%的一般做法的匿名数据。研究人员比较40岁及以上患者的记录。他们分析了30,000例血小板增多症,8 000例血小板计数正常者。

他们计算,如果只有5%的癌症患者的保守估计在癌症诊断之前有血小板增多症,其中有1/3有可能通过鉴定这种风险标记而将其诊断加速至少三个月,相当于每年5,500例早期诊断。

该研究揭示了第一个新的癌症指标,在30年内得到了强有力的证实。埃克塞特小组专门确定哪些症状预测癌症以辅助早期诊断,但是他们的大部分工作围绕量化已知的风险标记。血细胞增多症首先出现在调查其他特征时,本文是第一个彻底调查血小板增多症和未诊断癌症之间关联的文献。

埃克塞特大学医学院的威利·汉密尔顿教授说:“英国在早期癌症诊断方面远远落后于其他发达国家,2014年,这个国家有163,000人死于癌症,我们对血小板增多症的发现与癌症有很强的联系特别是在男性中,比女性乳腺癌乳房肿块强得多,现在推出血小板增多症的癌症调查至关重要,每年可以挽救数百人的生命。”

Ukoumunne博士得到了国家健康研究所协会在西南半岛应用保健研究和护理领域的领导支持。

原始出处:

Sarah ER Bailey, Obioha C Ukoumunne, et al. Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. Br J Gen Pract 22 May 2017; bjgp17X691109. DOI: https://doi.org/10.3399/bjgp17X691109

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    2017-05-24 反正

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1406998, encodeId=64a3140699872, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu May 25 04:24:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480169, encodeId=db28148016997, content=<a href='/topic/show?id=4892890598d' target=_blank style='color:#2F92EE;'>#血小板计数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89059, encryptionId=4892890598d, topicName=血小板计数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee9b7619292, createdName=12498877m100暂无昵称, createdTime=Thu May 25 04:24:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201973, encodeId=0c762019e3a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqgE6xZ8YaH0qaiaLKtuWxbvvEqX8qgSGfkiavaHP6tuo3qpnUefo1gK4oQdnKPjMdSQX6IchZ1ib2s/0, createdBy=317b1661419, createdName=反正, createdTime=Wed May 24 08:41:46 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201942, encodeId=4f29201942ae, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed May 24 07:50:36 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201924, encodeId=c51820192479, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed May 24 07:42:56 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201808, encodeId=854e201808dc, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed May 24 01:16:07 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201742, encodeId=2aff201e42b9, content=好好学习努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 23 19:22:21 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201714, encodeId=ca35201e140c, content=血小板增多症的发现与癌症有很强的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161019/IMG580762DBECE003340.jpg, createdBy=93fe1431842, createdName=FrankL, createdTime=Tue May 23 18:11:48 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201692, encodeId=865a201692a8, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Tue May 23 15:09:47 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-24 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1406998, encodeId=64a3140699872, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Thu May 25 04:24:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480169, encodeId=db28148016997, content=<a href='/topic/show?id=4892890598d' target=_blank style='color:#2F92EE;'>#血小板计数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89059, encryptionId=4892890598d, topicName=血小板计数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee9b7619292, createdName=12498877m100暂无昵称, createdTime=Thu May 25 04:24:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201973, encodeId=0c762019e3a2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqgE6xZ8YaH0qaiaLKtuWxbvvEqX8qgSGfkiavaHP6tuo3qpnUefo1gK4oQdnKPjMdSQX6IchZ1ib2s/0, createdBy=317b1661419, createdName=反正, createdTime=Wed May 24 08:41:46 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201942, encodeId=4f29201942ae, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed May 24 07:50:36 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201924, encodeId=c51820192479, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed May 24 07:42:56 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201808, encodeId=854e201808dc, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed May 24 01:16:07 CST 2017, time=2017-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201742, encodeId=2aff201e42b9, content=好好学习努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue May 23 19:22:21 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201714, encodeId=ca35201e140c, content=血小板增多症的发现与癌症有很强的联系, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161019/IMG580762DBECE003340.jpg, createdBy=93fe1431842, createdName=FrankL, createdTime=Tue May 23 18:11:48 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201692, encodeId=865a201692a8, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Tue May 23 15:09:47 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-24 184****9840

    学习了谢谢分享。

    0

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    2017-05-24 luominglian113

    学习了,谢谢分享

    0

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    2017-05-23 忠诚向上

    好好学习努力学习

    0

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    2017-05-23 FrankL

    血小板增多症的发现与癌症有很强的联系

    0

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    2017-05-23 139****5926

    好文章学习了

    0