Eur Radiol:肿瘤表面黏膜强化征——胃肠道间质瘤的高危预测因素

2021-03-09 shoasai MedSci原创

胃肠道间质瘤(GISTs)是胃肠道系统最常见的间质肿瘤,主要发生在胃(50-60%)、小肠(30-35%)、结肠和直肠(5%)和食道(< 1%)。

    胃肠道间质瘤(GISTs)是胃肠道系统最常见的间质肿瘤,主要发生在胃(50-60%)、小肠(30-35%)、结肠和直肠(5%)和食道(< 1%)。对于无转移的局灶性原发性GISTs的标准治疗是手术切除,因为这种肿瘤具有潜在的恶性倾向。而高危肿瘤则建议辅助治疗。因此,术前对胃肠道间质瘤进行准确的风险评估对于选择手术或辅助治疗变得越来越重要。

    表面粘膜强化征(OEGM)是重要的CT表现。已有多项研究报道了异位胰腺、胃腺癌相及低分化神经内分泌肿瘤OEGM的特点,很少有报道OEGM与胃黏膜和胃间质瘤危险因素关系的相关分析。


    由于高危肿瘤具有更强的侵袭性,我们推测高危的胃肠道间质瘤更容易引起腔内粘膜的侵袭和破坏。近日,发表在European Radiology杂志的一项研究通过观察胃GISTs的CT表现,证实了OEGM的CT特征可以作为GISTs术前的高风险预测因素并可用于预测危险分层。

    回顾性分析了由病理证实的GISTs的临床特点和CT表现。根据修改后的美国国立卫生研究院标准,将风险分层分为非高危组和高危组。进行单因素分析和多因素logistic回归分析,以确定高危分层的重要预测因素。进行受试者工作特征(ROC)曲线分析、亚组分析和病理-放射相关性分析。

表1 重要CT表现对胃GISTs高危分层的诊断价值及ROC曲线分析。ROC曲线分析显示,不完整的OEGM在诊断病变的曲线下面积值最大(0.835;95%置信区间,0.766 - 0.904;p < 0.001)。

表2 多因素logistic回归分析预测胃间质瘤高危分层。多因素分析显示,不完整的OEGM是GISTs高危分层的最强的独立预测因子(OR = 21.944;95%置信区间,4.344 - 110.863;p < 0.001)。

表3 完整OEGM和不完整OEGM之间的病理特征和重要的CT表现的比较。在亚组分析中,不完整的OEGM更常与肿瘤直径> 10 cm、形状不规则、外生生长模式、高有丝分裂计数和病理上黏膜破坏有关。

 

    不完整的OEGM征象是胃GISTs高危分层的独立预测因素,并且与病理性黏膜变化密切相关。这一术前CT特征有助于临床更优化的治疗方案的制定。


原始出处:

Gang Peng,Bingcang Huang,Xiaodan Yang,et al. Preoperative CT feature of incomplete overlying enhancing mucosa as a high-risk predictor in gastrointestinal stromal tumors of the stomach.DOI:10.1007/s00330-020-07377-5

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    2021-12-31 ms4000000609908410

    学习了

    0

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    2021-05-19 ゼロから

    谢谢分享,学习了

    0

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    2021-03-10 snowpeakxu
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    2021-03-10 科研科研科研

    胃肠道间质瘤的高危预测因素

    0

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    2021-03-09 carrotlyl

    感谢分享

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