J Clin Gastro: 胃食管反流病参与高血压患者的高血压形成

2018-09-02 MedSci MedSci原创

胃食管反流病(GERD)可能引发心血管疾病。许多因素都与原发性高血压的发生有关,但GERD是否也参与了高血压的形成还有待进一步研究。因此本研究评估了胃食管反流病(GERD)与高血压之间的关系,以及抗酸治疗是否可用于控制GERD患者的高血压血压(BP)。

背景及目标:
食管反流病(GERD)可能引发血管疾病。许多因素都与原发性高血压的发生有关,但GERD是否也参与了高血压的形成还有待进一步研究。因此本研究评估了食管反流病(GERD)与高血压之间的关系,以及抗酸治疗是否可用于控制GERD患者的高血压血压(BP)。

方法:
本研究共纳入原发性高血压患者 86名,通过24小时连续血压监测和食管阻抗pH监测来进行相关研究。符合GERD标准的患者接受奥美拉唑治疗14天(每天两次20 mg),并研究其对血压的影响。

结果:
86例原发性高血压患者中,38例(44.2%)患有GERD。在这38名患者中,记录了494次病理性反流(PR)和684次高血压发作。PR在夜间显着更常见,特别是在仰卧时。在684例高血压发作中,102例(14.9%)与PR发生同步。GERD患者的夜间血压明显高于非GERD患者。抗酸治疗使GERD患者的所有食管监测参数以及BP参数显着降低。

结论:
本研究表明高血压与GERD之间存在显着相关性。抗酸治疗可以恢复正常的食管pH值,并且有助于维持正常的血压。

原始出处:

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  5. 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createdName=一叶知秋, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571624, encodeId=a63715e1624a7, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342314, encodeId=f03334231421, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  6. 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target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448260, encodeId=416714482609b, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571624, encodeId=a63715e1624a7, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342314, encodeId=f03334231421, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun Sep 02 19:56:21 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-04 zhouqu_8
  7. 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  8. 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createdName=一叶知秋, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571624, encodeId=a63715e1624a7, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Tue Sep 04 06:16:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342314, encodeId=f03334231421, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun Sep 02 19:56:21 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-04 feifers
  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun Sep 02 19:56:21 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-02 王秀

    学习了,涨知识了!

    0