SCI REP:食管鳞状细胞癌患者代谢综合征和体重下降的预后作用

2018-07-10 MedSci MedSci原创

食管癌是常见的消化道恶性肿瘤,主要有两种类型:食管鳞状细胞癌和食管腺癌。其中鳞状细胞癌约占90%。SCI REP近期发表了一篇文章,研究代谢综合征与食管癌患者术后生存之间的关系,评估代谢综合征是否可以预测食管癌患者预后。

食管癌是常见的消化道恶性肿瘤,主要有两种类型:食管鳞状细胞癌和食管腺癌。其中鳞状细胞癌约占90%。SCI REP近期发表了一篇文章,研究代谢综合征与食管癌患者术后生存之间的关系,评估代谢综合征是否可以预测食管癌患者预后。

作者回顾性分析了2007年至2011年间接受食管切除术和淋巴结清扫的519例食管癌患者信息。患者随访时间至2016年12月。中位随访时间为39.95个月。3年生存率和5年生存率分别为51.4%和37.0%。K-M生存分析表明总生存与肥胖,体重下降,糖尿病和血脂异常显着相关。多因素分析表明TNM分期晚和体重下降大是食管鳞状细胞癌预后不良的独立预测因素。与之相反,糖尿病是食管鳞状细胞癌患者预后的有利因素。

文章最后认为,该研究结果表明TNF分期,体重改变和糖尿病是食管癌患者预后的独立预测因素。

原始出处:
Bowen Liu,Bo Cheng,et al.The prognositc significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma.SCI REP.04 July 2018 doi:10.1038/s41598-018-28268-2

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1978715, encodeId=cd3e19e8715bb, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Fri Mar 29 04:48:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378855, encodeId=797d13e8855c9, content=<a href='/topic/show?id=b860101129ac' target=_blank style='color:#2F92EE;'>#食管鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101129, encryptionId=b860101129ac, topicName=食管鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aae2431, createdName=venlin, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431264, encodeId=d4ef1431264e2, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437345, encodeId=95d1143e345d1, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1978715, encodeId=cd3e19e8715bb, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Fri Mar 29 04:48:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378855, encodeId=797d13e8855c9, content=<a href='/topic/show?id=b860101129ac' target=_blank style='color:#2F92EE;'>#食管鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101129, encryptionId=b860101129ac, topicName=食管鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aae2431, createdName=venlin, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431264, encodeId=d4ef1431264e2, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437345, encodeId=95d1143e345d1, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1978715, encodeId=cd3e19e8715bb, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Fri Mar 29 04:48:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378855, encodeId=797d13e8855c9, content=<a href='/topic/show?id=b860101129ac' target=_blank style='color:#2F92EE;'>#食管鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101129, encryptionId=b860101129ac, topicName=食管鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aae2431, createdName=venlin, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431264, encodeId=d4ef1431264e2, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437345, encodeId=95d1143e345d1, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1978715, encodeId=cd3e19e8715bb, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Fri Mar 29 04:48:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378855, encodeId=797d13e8855c9, content=<a href='/topic/show?id=b860101129ac' target=_blank style='color:#2F92EE;'>#食管鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101129, encryptionId=b860101129ac, topicName=食管鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aae2431, createdName=venlin, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431264, encodeId=d4ef1431264e2, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437345, encodeId=95d1143e345d1, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Jul 12 05:48:00 CST 2018, time=2018-07-12, status=1, ipAttribution=)]
    2018-07-12 zhouqu_8

相关资讯

EUR J Cancer:淋巴结照射和厄洛替尼治疗食管鳞状细胞癌

研究人员报道了一项随机III期临床研究,以研究淋巴结照射(ENI)和/或厄洛替尼在无法手术的食管鳞状细胞癌(ESCC)中的疗效。

Gastroenterology:中国科学家在食管癌领域取得重大突破,“搞定食管癌,还是得靠我们中国自己的科学家”

两周前,中国医学科学院和北京协和医学院的林东昕院士和吴晨教授在消化领域顶级期刊《Gastroenterology》上发表研究,他们发现BRCA1相关蛋白BRAP是食管鳞状细胞癌(ESCC)发展、转移的重要蛋白,显著增强了ESCC的侵袭性!这也为ESCC的精准治疗提供了一个可能的靶点。

Mol Cancer:研究发现食管鳞状细胞癌潜在的诊断及预后的靶点

近期研究发现食管鳞状细胞癌(ESCC)中多个长链非编码RNAs(lncRNAs)异常表达,但其作用机制仍不清楚的大多数。本研究旨在确定ESCC相关的lncRNAs并详细阐明其功能和机制。采用芯片分析在ESCC组织中差异表达的lncRNA,并采用qRT-PCR验证芯片结果。体内外研究中探究表达异常增加最甚的lncRNA——CASC9,对细胞的生长、增殖和细胞周期的作用。使用芯片和恢复测试发现CASC

Brit J Cancer:坚果摄入和食管鳞状细胞癌风险

由此可见,该研究发现,在这些高风险人群中,坚果总消耗量与ESCC风险之间存在统计学显著的负相关性。

Cell Death Dis:lnc-ATB可预测食管鳞状细胞癌患者的预后

食管鳞状细胞癌(ESCC)是癌症相关死亡的主要原因之一,特别是在中国。此外,晚期患者的预后极差。然而,长链非编码RNA lnc-ATB的生物学意义及其在ESCC中的潜在作用仍有待探究。在本研究中,研究人员探究了lnc-ATB在ESCC的作用及其促进自身致癌活性的潜在机制。 结果显示,ESCC组织和细胞系中lnc-ATB的表达水平高于正常对照组。lnc-ATB表达上调可作为ESCC患者的独立预后指标

Oncotarget:肿瘤免疫微环境因子竟然与食管鳞状细胞癌患者生存情况有关!

食管鳞状细胞癌(ESCC)是与预后不良相关的最常见的食管癌,需要额外治疗策略的实施来优化ESCC的治疗。