Hypertension:高血压成年人叶酸治疗对无卒中生存期的影响

2019-12-24 xing.T MedSci原创

总体而言,除了在某些亚组中具有显著益处外,与单独使用依那普利相比,依那普利加叶酸治疗的高血压患者无卒中生存期有一定延长。

中国卒中一级预防试验(CSPPT)显示,与单独使用依那普利治疗的高血压患者相比,依那普利加叶酸治疗的高血压患者首次卒中的风险显著降低,但与该治疗相关的无卒中生存期尚不明确。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员通过使用来自CSPPT的19053名参与者的数据建立针对竞争风险的调整模型和基于年龄的时间量表,估算了依那普利-叶酸与单独依那普利的无卒中生存期增量。

与单独使用依那普利相比,依那普利加叶酸治疗的平均无卒中生存期延长了1.75个月,四分位间距为0.73-2.39个月,最大延长期可达12.95个月。亚组分析显示,年轻的男性患者,基线叶酸水平较低,基线收缩压较高,基线总胆固醇和血糖较高且具有MTHFR(亚甲基四氢叶酸还原酶)C677T CT或TT基因型的患者无卒中生存期更长。

总体而言,除了在某些亚组中具有显著益处外,与单独使用依那普利相比,依那普利加叶酸治疗的高血压患者无卒中生存期有一定延长。

原始出处:

Tiantian Zhang.et al.Estimated Stroke-Free Survival of Folic Acid Therapy for Hypertensive Adults Projection Based on the CSPPT.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14102

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    2020-02-02 feather89
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    2019-12-24 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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