感染

订阅

MedSci主页 / 所有栏目 / 感染

JNNP:武汉市COVID-19大流行期间静脉溶栓治疗急性缺血性脑卒中：一项多中心、回顾性队列研究

2020-11-14 MedSci原创 MedSci原创

多中心缺血性脑卒中武汉市
关注

COVID-19已经成为一种全球性的流行病。这场迅速爆发的疫情使医疗体系不堪重负，医疗资源枯竭。令人担忧的是，许多患有其他疾病的患者无法得到及时治疗。中风是全世界死亡和残疾的主要原因。在COVID-1

COVID-19已经成为一种全球性的流行病。这场迅速爆发的疫情使医疗体系不堪重负，医疗资源枯竭。令人担忧的是，许多患有其他疾病的患者无法得到及时治疗。中风是全世界死亡和残疾的主要原因。在COVID-19流行的背景下，中风仍然是一种医学紧急情况。超早期静脉溶栓治疗急性缺血性脑卒中（AIS）具有高度的时效性。最近，有报道称，在流感大流行期间，到医院就诊的中风患者的流行病学观察研究报告减少。另一方面，中风在COVID-19患者中并不少见。在这里，作者在四个中风中心报告了AIS患者的静脉溶栓治疗在湖北武汉做疫情流行期间，并比较2019年同期提供的治疗。

本文回顾性分析了2019年1月1日至2020年3月30日在武汉协和医院、武汉普仁医院、武汉市东西湖区人民医院等4家医院接受组织纤溶酶原激活剂（tPA）治疗的两组AIS患者，三。在COVID-19流行期间，所有四家医院都不断收到急诊病例。最后期限是2020年4月30日。所有入选的AIS患者必须符合以下标准：（1）静脉注射tPA（0.9 mg/kg），（2）静脉注射tPA前后接受CT或MRI检查。所有经静脉注射tPA治疗的AIS患者在住院期间和随访期间均进行了喉拭子标本的实时逆转录聚合酶链反应（RT-PCR）分析和胸部CT扫描。根据世界卫生组织（WHO）的暂行指南，一例COVID-19确诊病例被定义为RT-PCR阳性结果。遵循《流行病学报告指南》加强观察性研究的报告。将中风亚型分为大动脉动脉粥样硬化（LAA）、心源性栓塞（CE）、小动脉闭塞（SAO）、其他病因确定的中风和未明病因的中风。记录起病至溶栓时间（ONT）、起病至入院时间（DNT）、国家卫生研究院卒中量表（NIHSS）。改良等级评定量表（mRS）评分在1个月时通过电话或面谈进行集中评估。记录所有出血事件和全因死亡率。

从2020年1月1日至2020年3月30日，共有683名患者因流行性中风入院，2019年同期收治1614名患者。其中67例AIS患者接受静脉rtPA治疗，2019年同期共治疗131例。2020年和2019年，静脉注射tPA合格患者的比例分别为9.81%和8.12%。患者的平均年龄分别为2020年66.55±13.01岁和2019年66.76±13.04岁。就中风亚型而言，与2019年相比，2020年更多的患者患有CE、LAA或未确定类型的中风（分别为16.4%和10.7%、43.3%和32.1%、10.4%和1.5%，p=0.008）。平均DNT为74.24±41.71（13～180） min，较上年同期（46.36±21.59 min，p<0.001）有所增加。ONT升高（199.34±68.95分钟vs 155.12±62.46分钟，p<0.001）。
 

研究表明，与2019年同期相比，COVID-19疫情期间的缺血性中风病例和溶栓病例总数明显减少。COVID-19的流行必然导致DNT延长。静脉注射rtPA仍然是有效的。

Zhou Y, Hong C, Chang J, et al Intravenous thrombolysis for acute ischaemic stroke during COVID‐19 pandemic in Wuhan, China: a multicentre, retrospective cohort study Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 28 October 2020. doi: 10.1136/jnnp-2020-324014

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (9)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-03-06 fusion

    #静脉#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-01-21 guihongzh

    #缺血性#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-08-19 luoxiaog

    #多中心#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2021-07-25 ms7524819409032184

    #缺血性脑#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-16 智智灵药

    #急性缺血性脑卒中#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-16 lqvr

    #溶栓治疗#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-16 bettycmoon

    #静脉溶栓治疗#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-15 124c4ba8m65暂无昵称

    😄

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1698163, encodeId=466e169816377, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Sat Mar 06 21:35:07 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893335, encodeId=1cc11893335a6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Jan 21 04:35:07 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904033, encodeId=8f911904033f1, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Thu Aug 19 22:35:07 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807149, encodeId=01b5180e149c7, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sun Jul 25 12:35:07 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259415, encodeId=4360125941583, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418587, encodeId=7b57141858e01, content=<a href='/topic/show?id=b88266482f7' target=_blank style='color:#2F92EE;'>#溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66482, encryptionId=b88266482f7, topicName=溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00673387794, createdName=lqvr, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537587, encodeId=c737153e58767, content=<a href='/topic/show?id=221799151b3' target=_blank style='color:#2F92EE;'>#静脉溶栓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99151, encryptionId=221799151b3, topicName=静脉溶栓治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4e9812877003, createdName=bettycmoon, createdTime=Mon Nov 16 14:35:07 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899231, encodeId=487189923120, content=😄, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68692513618, createdName=124c4ba8m65暂无昵称, createdTime=Sun Nov 15 07:13:31 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026713, encodeId=7fa71026e133c, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Nov 15 02:35:07 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-15 健健

    卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

    0

相关资讯

国际多中心药物临床试验指南（试行）

国家食品药品监督管理总局2015年第2号一、背景　　近年来，药物研发日益趋于全球化，用于药品注册的国际多中心药物临床试验，已经从人用药品注册技术要求国际协调会(ICH)区域拓展到非ICH区域。药物全球同步研发，是一种共享资源的开发模式，可以减少不必要的重复临床试验，缩短区域或国家间药品上市延迟，提高患者获得新药的可及性。境内申办者为融入国际市场，也越来越关注全球同步研发。　　申办者要根据早期研

中山大学完成全球AI医生多中心随机对照研究

5月6日，记者从中山大学中山眼科中心获悉，该中心教授刘奕志、林浩添眼科人工智能团队牵头完成全球首个AI医生多中心随机对照研究，为探索人工智能临床转化和落地应用标准，迈出了至关重要的一步。

CLIN CHEM LAB MED：多中心对Alinity hq血液分析仪性能评价

Alinity hq (Abbott)是一款新型高通量血液分析仪，通过采用光学原理对血细胞进行检测和计数。该仪器报告了29个参数，包括六部分的白细胞(WBC)差异。这项多中心研究的目的是评估Alinity hq的分析和临床表现。

颅内多中心少突星形细胞瘤1例

患者，男性，25岁，因“18d前突发抽搐1次”入院。既往身体健康，否认高血压、糖尿病及家族疾病史。

多中心骨巨细胞瘤伴肝肺转移1例

多中心骨巨细胞瘤（MCGCT）指同一患者发生的多于一处、并被组织病理学证实的骨巨细胞瘤。骨巨细胞瘤多为单发病灶，作为其中一种类型，多中心骨巨细胞瘤极为罕见，其发病率不足骨巨细胞瘤患者的1％。目前关于多中心骨巨细胞瘤文献资料均以个案报道为主，缺少多中心大样本数据。笔者曾于2017年12月收治1例多中心骨巨细胞瘤合并肝肺转移患者，现将诊治过程报道如下。

多中心临床试验中心效应的统计分析

多中心临床试验可以在较短的时间内招募到足够的病例数，同时，来自多个中心的病例比来自单中心的病例有更好的代表性，从而使得结论的外推性更可靠。但时，由于各中心的试验条件未必完全相同，同一中心数据具有相似性，而不同中心则会存在异质性，这种现象称为“中心效应（center effect）”。中心效应往往不可避免，特别是当主要疗效评价指标出现中心效应时，如果统计处理不当，所得结论将会产生偏性。 对