J Cell Mol Med:角膜缘细胞是成体间充质干细胞的有效来源

2018-04-30 cuiguizhong MedSci原创

深圳大学眼视光学院深圳眼科医院的Guo P近日在J Cell Mol Med发表了一篇文章,他们论述了角膜缘细胞是成体间充质干细胞的有效来源。

深圳大学眼视光学院深圳眼科医院的Guo P近日在J Cell Mol Med发表了一篇文章,他们论述了角膜缘细胞是成体间充质干细胞的有效来源。

角膜缘细胞是位于角膜缘基底上皮细胞旁边的间充质干细胞。角膜缘内环境细胞表达胚胎干细胞标志物,如Nanog、Nestin、Oct4、Rex1、Sox2和SSEA4,间充质细胞标志物,如CD73、CD90和CD105,以及血管生成标志物如Flk-1、CD31、CD34、VWF、PDGFRβ和α-SMA,但不表达CD45。此外,在三维环境中,角膜缘细胞的干细胞在细胞培养过程中可以保持干细胞的特性。角膜缘细胞具有在体外形成脂肪、软骨、成骨的能力,表明它们实际上是成人干细胞的宝贵资源。关于角膜缘细胞如何调节上述干细胞和向角膜缘命运特化的研究是必要的,因为这将有助于使用间充质干细胞来恢复角膜缘干细胞缺陷,并进行角膜缘细胞治疗。

原文出处:

Guo, P., et al., Limbal niche cells are a potent resource of adult mesenchymal progenitors. J Cell Mol Med, 2018.

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    2019-02-03 维他命
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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Sun May 06 10:54:56 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=311516, encodeId=a654311516e4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Thu May 03 06:44:47 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349135, encodeId=b4c31349135e5, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, 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encodeId=5ada31101290, content=什么时候能够临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfd52343418, createdName=12296b8em38暂无昵称, createdTime=Tue May 01 18:09:49 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310930, encodeId=677c31093058, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue May 01 08:55:31 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310925, encodeId=a85731092570, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-06 荒郊野树

    学习

    0

  5. 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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-03 荒郊野树

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1870601, encodeId=dcd318e060125, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue May 08 04:30:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815317, encodeId=01b3181531ef4, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=5ada31101290, content=什么时候能够临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfd52343418, createdName=12296b8em38暂无昵称, createdTime=Tue May 01 18:09:49 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310930, encodeId=677c31093058, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue May 01 08:55:31 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310925, encodeId=a85731092570, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-02 zhaojie88
  7. 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  8. 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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 12296b8em38暂无昵称

    什么时候能够临床

    0

  9. 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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 kafei

    学习了谢谢分享

    0

  10. 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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 01 08:28:05 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 明月清辉

    谢谢分享.学习了

    0

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青岛大学附属医院眼科的Niu Y近日在Invest Ophthalmol Vis Sci发表了一篇重要的工作, 他们确定了蛋白酶激活受体-2(PAR-2)在由烟曲霉感染的角膜中的作用。他们发现,烟曲霉可能通过p-ERK1 / 2来上调PAR-2的表达,促使疾病发展、多核中性粒细胞(PMN)浸润和促炎细胞因子的表达。

Exp Clin Transplant:供体角膜对穿透性角膜移植手术结果的影响

土耳其安卡拉培训与研究医院的眼科的Singar-Ozdemir E近日在Exp Clin Transplant发表了一篇文章,在这项研究中,他们比较了分别使用国产和进口供体角膜进行穿透性角膜移植术的手术效果。

Cornea:激光原位角膜磨镶术后眼睛中央上皮厚度与中央角膜厚度的关系

俄罗斯圣彼得堡军事医学科学院眼科的Maltsev DS近日在Cornea发表了一项工作,他们研究了健康人中央上皮厚度(CET)与中央角膜厚度(CCT)之间的关系,并评估其在激光原位角膜磨削术(LASIK)后的变化。

Cell Tissue Bank:建立猪角膜内皮器官培养模型!

德国Tübingen医院眼科中心的Kunzmann BC近日在Cell Tissue Bank杂志上发表了他们近期的一项工作,他们建立了与人角膜相当的猪角膜的器官培养模型。

Int J Mol Sci:干燥样泪腺角膜结膜炎的无菌小鼠模型

浙江大学医学院眼科研究所和贝勒医学院卡伦眼科研究所眼科中心眼科中心的Wang C近日在Int J Mol Sci发表了一项工作。共生细菌在免疫系统的形成中发挥重要作用,但它们在维持眼表面和泪腺的免疫稳态方面的作用仍然知之甚少。这项研究调查了无菌和常规C57BL / 6J小鼠眼睛和泪腺的表型。

Ophthalmologe:生物触觉角膜假体植入后患者的生活质量研究!

德国杜塞尔多夫大学的FringsA近日在Ophthalmologe杂志上发表了他们近期的一项工作,他们调查了在生物触觉植入角膜假体后,患者的生活质量情况。