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ACS Appl Mater Interfaces：光动力学和化学疗法的自组装奥沙利铂（IV）前药 - 卟啉缀合物可有效用于癌症的治疗

2019-04-20 不详 网络

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纳米医学已成为有效治疗癌症的有效策略。一种有用的方法是通过简便的超分子自组装过程开发无载体纳米药物。为了获得高治疗效果，一直在寻求将光动力疗法与化学疗法相结合。在这项工作中，我们设计了一种纳米载体（PEG-Por-CD：oxliPt（IV）-ada）与奥沙利铂前药（oxliPt（IV）-ada）和卟啉光敏剂（PEG-Por-CD）通过主客体相互作用组装而成。实现刺激响应性联合治疗。通过对宿主和客体

纳米医学已成为有效治疗癌症的有效策略。一种有用的方法是通过简便的超分子自组装过程开发无载体纳米药物。为了获得高治疗效果，一直在寻求将光动力疗法与化学疗法相结合。在这项工作中，我们设计了一种纳米载体（PEG-Por-CD：oxliPt（IV）-ada）与奥沙利铂前药（oxliPt（IV）-ada）和卟啉光敏剂（PEG-Por-CD）通过主客体相互作用组装而成。实现刺激响应性联合治疗。通过对宿主和客体分子之间结合比的优异空间控制，使用β-环糊精和金刚烷分别修饰卟啉和奥沙利铂，以制备两亲性宿主-客体复合物，用于随后自组装成治疗性纳米颗粒。

结果显示，获得的PEG-Por-CD：oxliPt（IV）-ada纳米颗粒表现出良好的胶体稳定性，平均流体动力学尺寸为164nm，同时在还原环境下进行分解以释放活性治疗物质。共聚焦成像证明了PEG-Por-CD：oxliPt（IV）-ada在细胞中有效积累的能力，并且在630nm光照射下在体外产生活性氧物质。与单一疗法相比，PEG-Por-CD：oxliPt（IV）-ada纳米粒子显示出3倍增强的细胞毒性和2倍的细胞凋亡增加。使用携带4T1肿瘤的小鼠的体内实验证实，纳米颗粒有效抑制肿瘤生长而不引起全身毒性。

由自组装方法构建的本发明的自我递送纳米系统不仅允许精确控制药物和光敏剂负载比，而且还消除了药物载体的全身毒性问题，为组合癌症治疗的进一步发展提供了解决方案。

原始出处：

Lim WQ, Yang G, et al., Self-Assembled Oxaliplatin(IV) Prodrug-Porphyrin Conjugate for Combinational Photodynamic and Chemotherapy. ACS Appl Mater Interfaces. 2019 Apr 19. doi: 10.1021/acsami.9b04557.

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    2020-02-25 ms3153534357578991

    #铂#

    0

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    2019-08-23 夏天与十三菇凉

    #FAC#

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    2019-07-25 shanyongle

    #ACE#

    0

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    2020-01-28 chg121

    #化学疗法#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1737605, encodeId=f31e1e376055b, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Tue Feb 25 11:17:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956758, encodeId=bef41956e5890, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Aug 23 21:17:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655933, encodeId=abb71655933fe, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Jul 25 09:17:00 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040582, encodeId=65a32040582b9, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Tue Jan 28 22:17:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810760, encodeId=d5f41810e60e8, content=<a href='/topic/show?id=3bc086308f6' target=_blank style='color:#2F92EE;'>#自组装#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86308, encryptionId=3bc086308f6, topicName=自组装)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Mon Jan 20 08:17:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279304, encodeId=764612e93040e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546319, encodeId=b82f15463196b, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364997, encodeId=470636499ee0, content=动力学有点不懂哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2622354286, createdName=122b9cbbm13暂无昵称, createdTime=Sat Apr 20 22:51:36 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2020-01-20 zhishijing

    #自组装#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1737605, encodeId=f31e1e376055b, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Tue Feb 25 11:17:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956758, encodeId=bef41956e5890, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Aug 23 21:17:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655933, encodeId=abb71655933fe, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Jul 25 09:17:00 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040582, encodeId=65a32040582b9, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Tue Jan 28 22:17:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810760, encodeId=d5f41810e60e8, content=<a href='/topic/show?id=3bc086308f6' target=_blank style='color:#2F92EE;'>#自组装#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86308, encryptionId=3bc086308f6, topicName=自组装)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Mon Jan 20 08:17:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279304, encodeId=764612e93040e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546319, encodeId=b82f15463196b, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364997, encodeId=470636499ee0, content=动力学有点不懂哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2622354286, createdName=122b9cbbm13暂无昵称, createdTime=Sat Apr 20 22:51:36 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-22 yaanren

    #ACS#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1737605, encodeId=f31e1e376055b, content=<a href='/topic/show?id=292f965e5b5' target=_blank style='color:#2F92EE;'>#铂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96575, encryptionId=292f965e5b5, topicName=铂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca4034296500, createdName=ms3153534357578991, createdTime=Tue Feb 25 11:17:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956758, encodeId=bef41956e5890, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Aug 23 21:17:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655933, encodeId=abb71655933fe, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Thu Jul 25 09:17:00 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040582, encodeId=65a32040582b9, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Tue Jan 28 22:17:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810760, encodeId=d5f41810e60e8, content=<a href='/topic/show?id=3bc086308f6' target=_blank style='color:#2F92EE;'>#自组装#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86308, encryptionId=3bc086308f6, topicName=自组装)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Mon Jan 20 08:17:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279304, encodeId=764612e93040e, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546319, encodeId=b82f15463196b, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Apr 22 11:17:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364997, encodeId=470636499ee0, content=动力学有点不懂哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2622354286, createdName=122b9cbbm13暂无昵称, createdTime=Sat Apr 20 22:51:36 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-22 luckyshitiancai_42705688

    #光动力#

    0

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    2019-04-20 122b9cbbm13暂无昵称

    动力学有点不懂哎

    0