JACC:心脏磁共振疤痕可预测慢性Chagas 心肌病患者的预后

2018-11-21 MedSci MedSci原创

慢性Chagas 心肌病(CCC)患者有很明显的心肌纤维化,引起心脏猝死风险大大增加。本研究的目的旨在评估心脏磁共振晚期钆增强(LGE)的疤痕存在是否预示着CCC患者的不良预后。本研究纳入了140名CCC患者(女性占52.1%,平均年龄57岁),并对其进行了心脏磁共振和LGE检查,主要终点事件是心源性死亡和室性心动过速的复合事件,次要终点事件是心源性死亡、持续性室性心动过速或心源性住院的复合事件。

慢性Chagas 心肌病(CCC)患者有很明显的心肌纤维化,引起心脏猝死风险大大增加。本研究的目的旨在评估心脏磁共振晚期钆增强(LGE)的疤痕存在是否预示着CCC患者的不良预后。

本研究纳入了140名CCC患者(女性占52.1%,平均年龄57岁),并对其进行了心脏磁共振和LGE检查,主要终点事件是心源性死亡和室性心动过速的复合事件,次要终点事件是心源性死亡、持续性室性心动过速或心源性住院的复合事件。经过平均34个月时间的随访,发生了11例心源性死亡、3次持续性室性心动过速和20次心源性住院。有71.4%的患者存在LGE疤痕,与无LGE的患者相比,有积极性LGE的患者的左室射血分数更低,左室舒张末期容积和左室质量更高。与无LGE疤痕患者相比,有LGE疤痕的患者的主要终点事件和次要终点事件的发生风险均更高。在多变量分析中,年龄和LGE面积与主要终点事件相关,年龄和低左室射血分数与次要终点事件的发生相关。

研究结果显示,在慢性Chagas 心肌病患者中,心脏磁共振晚期钆增强的疤痕较常见,且与不良预后明显相关。

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    2019-03-17 许安
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    2019-01-02 hbwxf
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createdName=许安, createdTime=Sun Mar 17 09:06:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1854234, encodeId=476c185423439, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jan 02 06:06:00 CST 2019, time=2019-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062365, encodeId=9861206236544, content=<a href='/topic/show?id=2198208e64' target=_blank style='color:#2F92EE;'>#AGA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2087, encryptionId=2198208e64, topicName=AGA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Wed Sep 25 06:06:00 CST 2019, time=2019-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326045, encodeId=d6bb1326045b6, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341638, encodeId=5b941341638be, content=<a href='/topic/show?id=24b8e37529a' target=_blank style='color:#2F92EE;'>#磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394116, encodeId=e3ef139411623, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401458, encodeId=6eb71401458e8, content=<a href='/topic/show?id=c818516291b' target=_blank style='color:#2F92EE;'>#心脏磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51629, encryptionId=c818516291b, topicName=心脏磁共振)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f342339746, createdName=mhzhuang@stu.e, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622358, encodeId=a349162235826, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353278, encodeId=a0893532e820, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed Nov 21 20:19:31 CST 2018, time=2018-11-21, status=1, ipAttribution=)]
    2019-09-25 vera_1203
  5. 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394116, encodeId=e3ef139411623, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401458, encodeId=6eb71401458e8, content=<a href='/topic/show?id=c818516291b' target=_blank style='color:#2F92EE;'>#心脏磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51629, encryptionId=c818516291b, topicName=心脏磁共振)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f342339746, createdName=mhzhuang@stu.e, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622358, encodeId=a349162235826, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353278, encodeId=a0893532e820, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed Nov 21 20:19:31 CST 2018, time=2018-11-21, status=1, ipAttribution=)]
  6. 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likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73752, encryptionId=24b8e37529a, topicName=磁共振)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394116, encodeId=e3ef139411623, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401458, encodeId=6eb71401458e8, content=<a href='/topic/show?id=c818516291b' target=_blank style='color:#2F92EE;'>#心脏磁共振#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51629, encryptionId=c818516291b, topicName=心脏磁共振)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f342339746, createdName=mhzhuang@stu.e, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622358, encodeId=a349162235826, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353278, encodeId=a0893532e820, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed Nov 21 20:19:31 CST 2018, time=2018-11-21, status=1, ipAttribution=)]
    2018-11-23 HinsMax
  8. 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createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Nov 23 11:06:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353278, encodeId=a0893532e820, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed Nov 21 20:19:31 CST 2018, time=2018-11-21, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1782949, encodeId=1ffe1e82949cd, content=<a href='/topic/show?id=027945e584' target=_blank style='color:#2F92EE;'>#Chagas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4575, encryptionId=027945e584, topicName=Chagas)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Fri Oct 18 13:06:00 CST 2019, time=2019-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072365, encodeId=efa620e23656d, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, 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  10. 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    2018-11-21 易水河

    学习学习

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