降脂治疗:载脂蛋白B应该控制在什么水平?

2017-07-20 郭艺芳 郭艺芳心前沿

什么是载脂蛋白?

什么是载脂蛋白?

血脂主要包括胆固醇与甘油三酯。这两种物质都不溶解于水,无法在血液中转运并进入细胞内,因此需要与一种特殊蛋白结合成可溶于水的物质。这种特殊蛋白就是载脂蛋白。载脂蛋白与胆固醇和甘油三酯所组成的可溶于水的物质就是脂蛋白。这就是说,脂蛋白中包含有胆固醇、甘油三酯、载脂蛋白等成分。载脂蛋白分很多种类型,其中载脂蛋白AI(简称ApoA1)与载脂蛋白B(简称ApoB)是化验单中最常出现的两个项目。载脂蛋白A1参与胆固醇的逆转运(通俗地讲就是把动脉粥样斑块中的胆固醇运送回肝脏处理掉),主要存在于高密度脂蛋白中,因而其临床含义与高密度脂蛋白相似。人们平时所说的“好胆固醇”(即高密度脂蛋白中所含的胆固醇)之所以好,就是因为胆固醇搭上了载脂蛋白A1这趟车。与之相对应,“坏胆固醇”所指的是低密度脂蛋白胆固醇,其之所以坏,是因为胆固醇搭上了载脂蛋白B这趟车。因此,载脂蛋白B的临床含义与低密度脂蛋白胆固醇相似。

载脂蛋白A1应该控制到多少?

虽然载脂蛋白A1水平增高与动脉粥样硬化性心血管疾病之间存在密切关系,但由于缺乏随机化干预试验证据,是否将其作为干预靶点尚存争议。新近颁布的“2017年AACE/ACE血脂异常管理与动脉粥样硬化疾病预防指南”对此做出了明确推荐。该指南认为,检测ApoB或ApoB/ApoA1比值有助于评估患者剩余心血管病风险,且ApoB可用于评估降胆固醇疗效。对于动脉粥样硬化性心血管病发生风险增加的者(包括确诊糖尿病者),推荐Apo B控制目标为<90mg/dL;确诊心血管病、或糖尿病合并≥1种危险因素的患者,推荐Apo B控制目标为<80mg/dL;极度高危患者(如急性冠脉综合征),推荐Apo B控制目标为<70mg/dL。

郭艺芳,主任医师,教授,医学博士,博士生导师。中国医师协会心血管内科医师分会常委(兼高血压工作委员会副主委)、中国医师协会高血压专业委员会常委、中华医学会老年医学分会委员、中国老年医学学会高血压分会副会长、河北省医学会老年医学分会主委、河北省医师协会高血压分会主委。《中华内科杂志》、《中华老年医学杂志》、《中华心血管病杂志》、《中华全科医师杂志》编委,《中华高血压杂志》与《中国心血管杂志》常务编委。

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    2020-06-24 148ccaa6m02暂无昵称

    问题是如何提高载脂蛋白A

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  5. [GetPortalCommentsPageByObjectIdResponse(id=799622, encodeId=771de9962228, content=问题是如何提高载脂蛋白A, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Wed Jun 24 23:10:10 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691552, encodeId=c6cb169155234, content=<a href='/topic/show?id=29ba9365035' target=_blank style='color:#2F92EE;'>#载脂蛋白B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93650, encryptionId=29ba9365035, topicName=载脂蛋白B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed8829226564, createdName=liubm565, createdTime=Mon Aug 28 18:12:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361287, encodeId=a387136128ee4, content=<a href='/topic/show?id=2c509364ea9' target=_blank style='color:#2F92EE;'>#载脂蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93647, encryptionId=2c509364ea9, topicName=载脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sat Jul 22 14:12:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424671, encodeId=228e14246e119, content=<a href='/topic/show?id=5a3b8441438' target=_blank style='color:#2F92EE;'>#脂蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84414, encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Sat Jul 22 14:12:00 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224968, encodeId=98962249684e, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 22 08:19:55 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224906, encodeId=7fbf224906c5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jul 22 07:17:10 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224449, encodeId=4792224449d6, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Fri Jul 21 05:35:54 CST 2017, time=2017-07-21, status=1, ipAttribution=)]
    2017-07-22 大爰

    学习了谢谢分享!!

    0

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    2017-07-22 龙胆草

    学习谢谢分享

    0

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    2017-07-21 189****1577

    值得推荐一下

    0

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该研究的目的是明确刷牙和心血管疾病,高血压(HT),糖尿病(DM),血脂异常(DL),高尿酸血症(HUA)和慢性肾脏病(CKD)风险因素之间的关系。该大型,单中心,横断面研究在2004年1月和2010年6月之间日本东京的圣路加国际医院,预防医学中心进行。本研究根据3类刷牙频率标准对85866人刷牙习惯进行了检测:“至少每天一次”和“不到一天一次”“每顿饭后”。根据频率得出的ORs计算了HT,DM,