Gut:亚太胃肠病学会和亚太消化内镜学会粪便微生物移植共识

2019-10-15 MedSci MedSci原创

专家组认为,在对不同疾病的治疗前景进行评估之前,FMT需要优化。这一结论为未来FMT研究和实践打下基础

粪便微生物移植(FMT)潜在的微生物基础、治疗结果的预测因子和活性成分尚不清楚。近日国际专家小组考察了FMT研究和临床实践的关键因素。

专家组对FMT文献进行了系统检索,并对FMT研究中的关键问题进行了为期1天的圆桌讨论。

16名专家召集并讨论了以下五个问题:(1)供体和受体微生物(细菌、病毒、真菌)参数在FMT中的作用;(2)评估微生物群变化的方法;(3)FMT的Keystone物种和微生物预测因子的概念;(4)受体分布和抗生素预处理对FMT植入和维护的影响;(5)FMT制剂和递送的新发展。专家组认为,FMT的可变结果与受体微生物群的组成和功能差异有关,可能与供体相关和受体相关的生理和遗传因素有关。供体肠道微生物群的分类组成可能影响FMT在复发性梭菌感染溃疡性结肠炎(UC)中的疗效。FMT不仅改变了细菌的组成,而且建立了肠道真菌、病毒和细菌之间的跨域平衡,以促进微生物稳态的恢复。FMT不能一概而论,需要进行研究,以鉴定在不同疾病患者中具有特定作用的微生物成分。

专家组认为,在对不同疾病的治疗前景进行评估之前,FMT需要优化。这一结论为未来FMT研究和实践打下基础。

原始出处:


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    2019-10-17 Homburg

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