Clin Trans Gastroenterology: 腹膜透析患者进行内窥镜检查也可以很安全

2021-07-15 MedSci原创 MedSci原创

腹膜炎是腹膜透析 (PD) 治疗中常见的并发症,会导致很高的死亡率。内窥镜手术在胃肠 (GI) 疾病的诊断和治疗中起着至关重要的作用,此类手术可通过刺激肠壁来

      腹膜炎是腹膜透析 (PD) 治疗中常见的并发症,会导致很高的死亡率。内窥镜手术在胃肠 (GI) 疾病的诊断和治疗中起着至关重要的作用,此类手术可通过刺激肠壁来增加 PD 患者发生腹膜炎的风险,导致微生物穿过肠壁转移到其他部位。PD 患者在内窥镜手术前是否普遍需要预防抗生素尚不清楚,因此,本研究的目的是评估 PD 患者内窥镜手术后腹膜炎的发生率。

 

      研究人员回顾性收集了2008 年至 2018 年在 3 家三级医院接受内窥镜检查的 PD 患者的数据。将患者分为非预防性、预防性和既往抗生素治疗组,然后评估了内窥镜检查后 7 天内腹膜炎的发生率。

 

      研究结果显示在 570 名 PD 患者中进行了 1316 次内窥镜检查。内镜检查后腹膜炎发生率为3.0%。具体而言,食管胃十二指肠镜检查的腹膜炎发生率为 1.8%,结肠镜检查组为 4.2%,乙状结肠镜检查组为 5.3%。既往抗生素治疗组显示出显着更高的腹膜炎风险(HR = 4.6;95%CI:2.2-9.6;P < 0.01)。预防性抗生素与减少腹膜炎无关。治疗性结肠镜检查(如息肉切除术)与发生腹膜炎的风险增加有关(OR = 6.5;95%CI:1.6-25.9),然而,活检与腹膜炎风险增加无关。

图:腹膜炎危险因素分析

      本项研究证实预防性使用抗生素并不能降低 PD 患者内镜检查后发生腹膜炎的风险。治疗性结肠镜检查,如息肉切除术和内窥镜检查前的既往抗生素治疗与腹膜炎风险增加有关。

 

 

原始出处:

Kim, Joon Sung. Et al. Safety of Endoscopy in Peritoneal Dialysis Patients. Clinical and Translational Gastroenterology.2021.

 

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    2022-03-07 bsmagic9140
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    2021-09-04 许安
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  5. 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  6. 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