Exp Gerontol:骨关节炎可能会增加动脉粥样硬化的发病风险

2022-04-27 sunshine MedSci原创

心血管疾病(CVD)仍然是全球死亡的主要原因,而动脉粥样硬化(AT)是该疾病过程的主要病理生理机制。既往研究中,有学者提出骨关节炎(OA)和AT之间可能存在关联,但证据是有争议的。

心血管疾病(CVD)仍然是全球死亡的主要原因,而动脉粥样硬化(AT)是该疾病过程的主要病理生理机制。既往研究中,有学者提出骨关节炎(OA)和AT之间可能存在关联,但证据是有争议的,最近的荟萃分析也显示了不同的结果。为了更好地探究这种可能的关联,研究人员进行了一项系统回顾和荟萃分析,将OA按关节(即髋关节和膝关节、手和一般OA)进行细分,并将结果按亚临床AT、显性心血管(CV)疾病和CV死亡进行分层。研究结果已在线发表于Exp Gerontol。

研究人员使用MeSH检索词 "骨关节炎"、"主动脉"、"颈动脉"、"内膜中层厚度"、"冠状动脉疾病"、"动脉粥样硬化"、"心血管疾病 "和 "死亡",检索了2021年9月之前PubMed、Web of Science、LILACS和SciELO收据库收录的相关文章。

结果,共纳入49项研究,包括552857名OA患者和688820名健康对照组,被纳入叙述性综述,33项研究纳入荟萃分析。除5项研究外,所有研究的质量都被认为是一般或良好。分析结果显示,髋关节OA和膝关节OA增加了亚临床AT(OR 1.15,95% CI 1.01-1.31)和CV疾病(OR 1.13,95% CI 1.05-1.22)的发病风险,但并没有增加CV死亡的风险(OR 1.08,95% CI 0.99-1.19)。手部OA与亚临床AT的发病风险升高有关(OR 1.18,95% CI 1.02-1.36),但与CV疾病(OR 1.49,95% CI 0.90-2.46)或CV死亡(OR 1.02,95% CI 0.73-1.44)无关。

综上所述,该研究结果表明,OA与亚临床AT有关,但仅在负重关节中,OA与CV疾病有关。即使OA和CV死亡之间有正相关的趋势,但未达到有统计学意义。

原始出处:

Marina Barguil Macêdo, et al., Association between osteoarthritis and atherosclerosis: A systematic review and meta-analysis. Exp Gerontol. 2022 May;161:111734. doi: 10.1016/j.exger.2022.111734. Epub 2022 Feb 10.

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    2022-06-24 lisa438
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    2022-04-27 lmm397

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