J Photochem Photobiol B:优化光动力疗法(PDT)对痤疮的治疗,以长期缓解症状并减少副作用

2021-10-16 MedSci原创 MedSci原创

寻常性痤疮是一种慢性炎症,其发病机制涉及多种因素,包括皮脂分泌增加、炎症、角质化改变和痤疮杆菌的定植,严重影响了青少年的情绪和心理健康。氨基酮酸甲酯光动力疗法(MAL-PDT)是治疗寻常性痤疮的有效方

寻常性痤疮是一种慢性炎症,其发病机制涉及多种因素,包括皮脂分泌增加、炎症、角质化改变和痤疮杆菌的定植,严重影响了青少年的情绪和心理健康。氨基酮酸甲酯光动力疗法(MAL-PDT)是治疗寻常性痤疮的有效方法,但存在较多的副作用。近日,发表于J Photochem Photobiol B的一项前瞻性的随机分面研究旨在优化MAL-PDT治疗。

研究共纳入33名患者,随机分配到一个脸颊上使用MAL和另一个脸颊上使用安慰剂的PDT的两个或四个治疗中,间隔1-2周。使用MAL霜进行1.5小时的预处理,然后用红光(20J/cm2)照射。在治疗前和最后一次治疗后4、10和20周进行评估。

 

结果显示,与基线相比,用MAL-PDT治疗的脸颊在20周时的炎症病变数量显示,两次治疗的组别相对减少了74%,四次治疗的组别则减少了85%。MAL-PDT和安慰剂-PDT双方的炎症或非炎症性病变的相对变化没有显著差异。MAL-PDT一侧疼痛(VAS中位数:1.85)明显高于安慰剂-PDT一侧(VAS中位数:0.0)。根据DLQI评分的中位数,生活质量从基线的7.5分提高到第20周的2.0分。

综上所述,该研究结果表明,这种针对MAL-PDT和纯红光PDT的新治疗方案,缩短了治疗前的时间,减少了光照剂量,取得的效果可以持续20周,而且副作用可以忍受。未来需要研究单独使用红光或与其他外用治疗方法联合使用的疗效和安全性。

 

原始出处:

 

Karolina Wojewoda, et al., Optimizing treatment of acne with photodynamic therapy (PDT) to achieve long-term remission and reduce side effects. A prospective randomized controlled trial. J Photochem Photobiol B. 2021 Oct;223:112299. doi: 10.1016/j.jphotobiol.2021.112299. 

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    2022-06-22 liuxiaona
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    2022-08-10 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1815142, encodeId=6d1f181514222, content=<a href='/topic/show?id=12069e036e5' target=_blank style='color:#2F92EE;'>#长期缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97036, encryptionId=12069e036e5, topicName=长期缓解)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue May 17 16:44:31 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788738, encodeId=bfda1e887382b, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Wed Jun 22 02:44:31 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824373, encodeId=87bc18243e301, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Dec 11 00:44:31 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919324, encodeId=81e11919324cd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 10 11:44:31 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767869, encodeId=e2491e6786908, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Aug 17 09:44:31 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661521, encodeId=047f1661521cc, content=<a href='/topic/show?id=73a3139e4e9' target=_blank style='color:#2F92EE;'>#PDT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13974, encryptionId=73a3139e4e9, topicName=PDT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e35e25313849, createdName=江川靖瑶, createdTime=Sun Sep 04 17:44:31 CST 2022, time=2022-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546340, encodeId=af4015463405c, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Oct 18 03:44:31 CST 2021, time=2021-10-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1815142, encodeId=6d1f181514222, content=<a href='/topic/show?id=12069e036e5' target=_blank style='color:#2F92EE;'>#长期缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97036, encryptionId=12069e036e5, topicName=长期缓解)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Tue May 17 16:44:31 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788738, encodeId=bfda1e887382b, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Wed Jun 22 02:44:31 CST 2022, time=2022-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824373, encodeId=87bc18243e301, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Dec 11 00:44:31 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919324, encodeId=81e11919324cd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Aug 10 11:44:31 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767869, encodeId=e2491e6786908, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Aug 17 09:44:31 CST 2022, time=2022-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661521, encodeId=047f1661521cc, content=<a href='/topic/show?id=73a3139e4e9' target=_blank style='color:#2F92EE;'>#PDT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13974, encryptionId=73a3139e4e9, topicName=PDT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e35e25313849, createdName=江川靖瑶, createdTime=Sun Sep 04 17:44:31 CST 2022, time=2022-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546340, encodeId=af4015463405c, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Oct 18 03:44:31 CST 2021, time=2021-10-18, status=1, ipAttribution=)]
    2022-09-04 江川靖瑶
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