Ann Neurol:缺血性卒中后癫痫发作

2021-09-13 MedSci原创 MedSci原创

卒中后癫痫发作与卒中严重程度、病因和位置有关,而早期脑电图不能预测癫痫。研究人员没有发现再灌注治疗与急性症状性癫痫发作或卒中后癫痫风险之间存在关联。

近日,神经病学领域权威取杂志Annals of Neurology上发表了一篇研究文章,这项研究旨在明确急性缺血性卒中后急性症状性癫痫发作和卒中后癫痫的危险因素,并评估再灌注治疗的效果。

这项多中心研究使用了Logistic或Cox回归评估了卒中后癫痫发作的危险因素,该研究纳入了来自八个欧洲转诊中心的神经影像学确诊的缺血性卒中的成年人。研究人员在倾向评分匹配后比较了接受或不接受再灌注治疗的参与者卒中后癫痫发作的风险,以减少由于治疗选择造成的混淆。

在4229名参与者(平均年龄为71岁,57%为男性)的整体队列中,在卒中更严重、大脑后动脉区域梗塞和大动脉粥样硬化引起的卒中的患者中观察到急性症状性癫痫发作的风险更高。由小血管闭塞引起的卒中发生急性症状性癫痫发作的风险很小。6%的患者发展为卒中后癫痫。

卒中后癫痫的危险因素是急性症状性癫痫发作、更严重的卒中、涉及大脑皮层的损伤以及大动脉粥样硬化引起的卒中。卒中发作后7天内的脑电图结果与卒中后癫痫的风险并无独立相关。一般再灌注治疗或仅静脉溶栓或机械取栓与卒中后癫痫时间或急性症状性癫痫发作风险之间没有关联。
 
由此可见,卒中后癫痫发作与卒中严重程度、病因和位置有关,而早期脑电图不能预测癫痫。研究人员没有发现再灌注治疗与急性症状性癫痫发作或卒中后癫痫风险之间存在关联。

原始出处:

Carolina Ferreira-Atuesta.et al.Seizures after ischemic stroke: a matched multicenter study.Annals of Neurology.2021.https://doi.org/10.1002/ana.26212

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  5. 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    2022-08-25 yinhl1978
  6. 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    2021-09-14 查查佳佳

    么比睡觉咯预测监控的JJ

    0

  7. 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createdBy=66ec123, createdName=guihongzh, createdTime=Tue Mar 01 05:49:40 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001469, encodeId=8bbb2001469f4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Aug 25 02:49:40 CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050160, encodeId=e0fc105016097, content=么比睡觉咯预测监控的JJ, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Sep 14 07:29:11 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050128, encodeId=956c1050128ac, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd8c5593896, createdName=Melissa_MoMo, createdTime=Tue Sep 14 02:40:55 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026960, encodeId=ab0a102696075, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052599, encodeId=f641105259905, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1017052, encodeId=a7bf101e05227, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>后<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>发作,可能是局灶性脑坏死,从而引发癫痫了, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中), TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon Sep 13 15:05:49 CST 2021, time=2021-09-13, status=1, ipAttribution=)]
    2021-09-14 Melissa_MoMo

    谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1671444, encodeId=4bbc16e1444b4, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Wed May 18 04:49:40 CST 2022, time=2022-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806457, encodeId=4e7a180645ef3, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Wed Apr 20 20:49:40 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195218, encodeId=c5b611952183f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b23462159, createdName=130a765fm69暂无昵称, createdTime=Sat Feb 19 22:40:03 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893415, encodeId=90551893415cb, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Mar 01 05:49:40 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001469, encodeId=8bbb2001469f4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Aug 25 02:49:40 CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050160, encodeId=e0fc105016097, content=么比睡觉咯预测监控的JJ, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Sep 14 07:29:11 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050128, encodeId=956c1050128ac, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd8c5593896, createdName=Melissa_MoMo, createdTime=Tue Sep 14 02:40:55 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026960, encodeId=ab0a102696075, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052599, encodeId=f641105259905, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1017052, encodeId=a7bf101e05227, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>后<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>发作,可能是局灶性脑坏死,从而引发癫痫了, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中), TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon Sep 13 15:05:49 CST 2021, time=2021-09-13, status=1, ipAttribution=)]
    2021-09-13 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  9. 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createdBy=66ec123, createdName=guihongzh, createdTime=Tue Mar 01 05:49:40 CST 2022, time=2022-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001469, encodeId=8bbb2001469f4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Aug 25 02:49:40 CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050160, encodeId=e0fc105016097, content=么比睡觉咯预测监控的JJ, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Tue Sep 14 07:29:11 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050128, encodeId=956c1050128ac, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd8c5593896, createdName=Melissa_MoMo, createdTime=Tue Sep 14 02:40:55 CST 2021, time=2021-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026960, encodeId=ab0a102696075, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052599, encodeId=f641105259905, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1017052, encodeId=a7bf101e05227, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>后<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>发作,可能是局灶性脑坏死,从而引发癫痫了, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中), TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon Sep 13 15:05:49 CST 2021, time=2021-09-13, status=1, ipAttribution=)]
    2021-09-13 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052599, encodeId=f641105259905, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Sep 13 15:49:40 CST 2021, time=2021-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1017052, encodeId=a7bf101e05227, content=<a href='/topic/show?id=fa10e93597f' target=_blank style='color:#2F92EE;'>#缺血性卒中#</a>后<a href='/topic/show?id=09f0e1554e6' target=_blank style='color:#2F92EE;'>#癫痫#</a>发作,可能是局灶性脑坏死,从而引发癫痫了, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79359, encryptionId=fa10e93597f, topicName=缺血性卒中), TopicDto(id=71554, encryptionId=09f0e1554e6, topicName=癫痫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon Sep 13 15:05:49 CST 2021, time=2021-09-13, status=1, ipAttribution=)]
    2021-09-13 病毒猎手

    #缺血性卒中##癫痫#发作,可能是局灶性脑坏死,从而引发癫痫了

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