JAHA:性别对冠心病患者总疾病负担和预后的影响

2019-03-01 不详 MedSci原创

总动脉粥样硬化疾病负担与冠心病患者的预后相关,然而,性别对总动脉粥样硬化疾病负担与预后并发症关系的影响尚不清楚。本研究纳入了1136名三条主要冠脉都接受了部分流量储备(FFR)检测的患者,通过SYNTAX 评分对患者的解剖和生理总疾病负担进行了评估,主要终点事件是主要不良心血管事件,2年的心源性死亡、心梗和缺血驱动的血运重建的复合事件。分析结果显示,男女性之间的冠脉直径和SYNTAX 评分无明显差

总动脉粥样硬化疾病负担与冠心病患者的预后相关,然而,性别对总动脉粥样硬化疾病负担与预后并发症关系的影响尚不清楚。

本研究纳入了1136名三条主要冠脉都接受了部分流量储备(FFR)检测的患者,通过SYNTAX 评分对患者的解剖和生理总疾病负担进行了评估,主要终点事件是主要不良血管事件,2年的心源性死亡、心梗和缺血驱动的血运重建的复合事件。分析结果显示,男女性之间的冠脉直径和SYNTAX 评分无明显差异,然而,每条血管的FFR(0.89±0.10 vs 0.87±0.11, P<0.001)和三条血管的FFR(2.72±0.13 vs 2.69±0.15, P<0.001)在女性中明显更高。多元回归分析发现解剖和生理总疾病负担与患者2年的主要不良心血管事件呈明显相关性,且性别与总疾病负担对预后没有相互作用。

研究结果显示,尽管血管造影显示的疾病严重程度在男女性间无明显差异,但是冠脉血管的生理学疾病严重程度在女性中更低,性别对冠心病患者总疾病负担和预后无明显影响。

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    2019-03-03 zhaohui6731
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    2019-03-01 王秀

    学习了,涨知识了!

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