Thromb Haemost:SCAD的治疗—替格瑞洛能否取代氯吡格雷?

2017-03-26 MedSci MedSci原创

近期,Thromb Haemost杂志中的一篇报道,对替格瑞洛与氯吡格雷,在稳定性冠脉疾病(SCAD)伴有慢性阻塞性肺疾病(COPD)患者中的疗效进行了对比。这两种药物中,哪种药物对于改善动脉内皮功能的作用更优呢?对于SCAD合并有COPD的患者,其心血管不良事件的发生率较一般人显着提高。慢性炎症、上皮功能失调、氧化应激、及血小板活性(PR)的增强均是不良事件的诱因。46名SCAD合并COPD的患

近期,Thromb Haemost杂志中的一篇报道,对替格瑞洛与氯吡格雷,在稳定性冠脉疾病(SCAD)伴有慢性阻塞性肺疾病(COPD)患者中的疗效进行了对比。这两种药物中,哪种药物对于改善动脉内皮功能的作用更优呢?

对于SCAD合并有COPD的患者,其血管不良事件的发生率较一般人显着提高。慢性炎症、上皮功能失调、氧化应激、及血小板活性(PR)的增强均是不良事件的诱因。

46名SCAD合并COPD的患者接受了经皮冠脉介入(PCI)检查后,被随机分在了替格瑞洛组(n=23)与氯吡格雷组(n=23),并联合阿司匹林口服进行标准的治疗。 测得一下参数作为基线,并与1月后相比较:1、细胞凋亡率;2、人脐静脉上皮细胞内一氧化氮(NO)的水平(HUVECs);3、外周血单个核细胞中活性氧(ROS)的水平;4、29细胞因子/趋化因子;5、治疗过程中的PR。这项研究的治疗终点为HUVECs细胞凋亡率。

研究结果表明:使用替格瑞洛组的患者,一月后的检测结果提示,细胞凋亡率显着降低(7.4 ± 1.3% vs 9.3 ± 1.5%, p<0.001),符合预先估计的主要终点。在替格瑞洛组,NO的水平较高,而ROS的水平降低。组间的细胞因子/趋化因子及阿司匹林的反应无差异。

该研究最终得出结论,替格瑞洛用于治疗SCAD合并COPD的患者,有助于血管内皮细胞功能的改善及血小板活性的调节,作用较氯吡格雷更优。

原始出处:

Campo G,Vieceli Dalla Sega F,Pavasini R,et al.Biological effects of ticagrelor over clopidogrel in patients with stable coronary artery disease and chronic obstructive pulmonary disease.Thromb Haemost. 2017 Mar 23. doi: 10.1160/TH16-12-0973.

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    2017-04-03 changfy
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    2017-03-28 zhangph
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    2017-03-27 cqykthl

    替格瑞洛疗效要好些,但是价格偏贵。

    0

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    2017-03-27 1e147e00m93(暂无匿称)

    替格瑞洛要贵的多

    0

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    2017-03-27 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2008235, encodeId=0623200823563, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Mon Apr 03 19:02:00 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531283, encodeId=c12e1531283bc, content=<a href='/topic/show?id=542d15951ab' target=_blank style='color:#2F92EE;'>#SCAD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15951, encryptionId=542d15951ab, topicName=SCAD)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06912243807, createdName=zhangph, createdTime=Tue Mar 28 10:02:00 CST 2017, time=2017-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183127, encodeId=2d8a18312ea9, content=替格瑞洛疗效要好些,但是价格偏贵。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Mon Mar 27 23:37:20 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183036, encodeId=06651830361d, content=替格瑞洛要贵的多, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83561965054, createdName=1e147e00m93(暂无匿称), createdTime=Mon Mar 27 09:53:05 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183022, encodeId=931e1830225b, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Mar 27 09:00:49 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182943, encodeId=d63a182943a7, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 27 01:07:51 CST 2017, time=2017-03-27, status=1, ipAttribution=)]
    2017-03-27 飛歌

    学习了很有用

    0

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