JAMA Cardiology:性别对单根与多根移植动脉CABG术的长期影响

2021-01-03 MedSci原创 MedSci原创

女性CABG术前风险往往比男性高。在低风险患者中,多动脉移植与更好的结果有关,但性别之间的风险截止点不同。这些数据提示应对女性多动脉移植结果进行进一步的研究。

冠状动脉旁路移植术是目前成人心脏外科最常见的手术。去年10月,JAMA子刊的meta分析比较了PCICABG治疗冠心病患者的全因死亡率和病因特异性死亡率差异,发现与接受CABG的患者相比,接受PCI治疗术后5年,冠心病患者的全因、心脏性和非心脏性死亡风险均较高。

那么在CABG术中,性别对单根与多根移植动脉CABG术有何长期影响?为此,来自美国纽约大学奥尔巴尼分校、西奈山医学院以及耶鲁大学的专家团队对性别对CABG期间使用多根动脉移植与单根动脉移植的结果进行了研究。相应结果发表在JAMA cardiocology杂志上。

研究人员使用了美国纽约州心脏手术报告系统和纽约生命统计档案中的数据,对200511-20141231日接受CABG多动脉移植术或单动脉移植术的63402例患者进行统计。统计分析时间为2020110-820日。

主要比较了倾向匹配的患者死亡率、急性心肌梗死AMI)、卒中、反复血管重建、主要不良心脑血管事件(死亡率、AMI和卒中的复合)和主要不良心脏事件(死亡率、AMI或反复血管重建的复合)情况,并按长期死亡风险进行分层。

共有63402名患者(48155名男性[76.0%];平均年龄,69.9岁)纳入该项研究。女性在大多数探索变量中的基线特征比男性差。倾向性匹配共产生了9512对男性和1860对女性。在7年的随访中,接受多支动脉移植的男性死亡率较低(调整后的危险比aHR=0.80;95% CI,0.73-0.87),但接受多支动脉移植的女性死亡率却不低(aHR=0.99;95% CI,0.84-1.15)。

当按死亡风险评估进行分层时,在低风险而非高风险的男女患者中,使用多动脉移植与更好的生存率和较低的重大不良心脏事件发生率相关,而且男性和女性的风险分界点不同。

由此可见,女性CABG术前风险往往比男性高。在低风险患者中,多动脉移植与更好的结果有关,但性别之间的风险截止点不同。这些数据提示应对女性多动脉移植结果进行进一步的研究。

 

参考文献:

Gaudino M, et al. Differences in Long-term Outcomes After Coronary Artery Bypass Grafting Using Single vs Multiple Arterial Grafts and the Association With Sex. JAMA Cardiol. 2020 Dec 23. doi: 10.1001/jamacardio.2020.6585.

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    2021-01-09 zb1235672
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    2021-01-03 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2053288, encodeId=6e92205328854, content=<a href='/topic/show?id=6d7796998e0' target=_blank style='color:#2F92EE;'>#长期影响#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96998, encryptionId=6d7796998e0, topicName=长期影响)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Thu Jun 10 12:36:13 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782107, encodeId=78a51e8210731, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Jul 14 19:36:13 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069289, encodeId=cd74206928917, content=<a href='/topic/show?id=125e40988d' target=_blank style='color:#2F92EE;'>#Cardiology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4098, encryptionId=125e40988d, topicName=Cardiology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=316c73, createdName=caoliehu, createdTime=Mon Mar 08 15:36:13 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915026, encodeId=1bc391502669, content=<a href='/topic/show?id=36663946ec' target=_blank style='color:#2F92EE;'>#CABG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3946, encryptionId=36663946ec, topicName=CABG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 21:47:34 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036385, encodeId=2e901036385f6, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Jan 03 14:36:13 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=913274, encodeId=ca1a9132e43f, content=CABG的预后还有性别差异, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210102/62b283b94f6d49ceace9b645eefc8434/72efab23a2a24d8ba614e46b19051092.jpg, createdBy=8a9c5449245, createdName=子茵, createdTime=Sun Jan 03 12:05:04 CST 2021, time=2021-01-03, status=1, ipAttribution=)]
    2021-01-03 子茵

    CABG的预后还有性别差异

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