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CELL：微生物-肠-脑轴

2021-05-21 MedSci原创 MedSci原创

微生物-肠-脑轴
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肠道微生物对大脑发育的影响

肠道微生物对大脑发育的影响 肠道微生物群从生命的最初阶段就开始影响宿主的生理特性。肠道微生物群的改变可能会对包括大脑在内的器官系统发育的关键过程造成损害。对无菌饲养、抗生素治疗或受改变母体或产后早期微生物群的环境因素影响的动物研究显示，通过调节神经元的产生、特性和成熟，大脑免疫、血脑屏障通透性、大脑结构和神经回路出现异常。这些影响会持续正在迅速出现，整个成年生活，并容易导致长期的行为缺陷，这凸显了在关键的神经发育窗口期，良好平衡的微生物群的重要性。虽然微生物组影响胎儿稳态的证据但需要进一步的研究来揭示肠道微生物调节早期大脑发育和成熟的精确机制。 肠道微生物群和大脑之间的交叉交流 肠道微生物群与中枢神经系统(CNS)之间的主动沟通可以通过至少三条平行且相互连接的路径来实现。 免疫 肠道微生物与肠道免疫系统密切相互作用。微生物产物，包括代谢产物，如短链脂肪酸(SCFAs)和膜成分，如多糖A，形成免疫稳态和局部免疫反应促炎或抗炎状态。微生物与局部免疫细胞的相互作用可以导致超出胃肠道的功能变化—例如，通过改变进入体循环的细胞因子的释放，或通过调节位于包括大脑在内的身体其它部位的免疫细胞。除了微

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  1. 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    2021-06-02 wjcjjian

    #微生物#

    0

  2. 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    2022-01-09 zhaozhouchifen

    #Cell#

    0

  3. 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    2021-11-09 赵八爷

    好东西 学到了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1825281, encodeId=0ad7182528117, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jun 02 21:28:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872214, encodeId=025d18e22140b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jan 09 00:28:12 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068777, encodeId=4dd51068e771a, content=好东西 学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eodb9QgicrLYiaMpYYNrS5bh4l2oVxUu73PUHsbIQX0yYSN2SiaOaP7GBZbygWF0wQRAbaZAIOBjbLhA/132, createdBy=4b1e2361466, createdName=赵八爷, createdTime=Tue Nov 09 22:25:57 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053045, encodeId=a6ed105304527, content=正好需要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9615438799, createdName=ms5000001066050641, createdTime=Sun Sep 19 16:53:31 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962524, encodeId=8d08196252442, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 06 20:28:12 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082976, encodeId=c9c820829e637, content=<a href='/topic/show?id=422e50661bf' target=_blank style='color:#2F92EE;'>#微生物-肠-脑轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50661, encryptionId=422e50661bf, topicName=微生物-肠-脑轴)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Sun Feb 06 16:28:12 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996275, encodeId=e4589962e5cd, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2cd5528102, createdName=ms4000001358121555, createdTime=Mon Jul 05 00:25:14 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973413, encodeId=65a99e341314, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Jun 14 10:38:10 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967917, encodeId=291a96e917b5, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27355466082, createdName=ms4000000724907591, createdTime=Sun May 23 14:12:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967620, encodeId=64d696e62095, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/0456f89e128a46948e578a75312c8d3c/e466bb6c0b644e8196e18e045a30a0f0.jpg, createdBy=1c165082954, createdName=145b8a5bm09暂无昵称, createdTime=Fri May 21 22:53:15 CST 2021, time=2021-05-21, status=1, ipAttribution=)]
    2021-09-19 ms5000001066050641

    正好需要这个

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1825281, encodeId=0ad7182528117, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jun 02 21:28:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872214, encodeId=025d18e22140b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jan 09 00:28:12 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068777, encodeId=4dd51068e771a, content=好东西 学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eodb9QgicrLYiaMpYYNrS5bh4l2oVxUu73PUHsbIQX0yYSN2SiaOaP7GBZbygWF0wQRAbaZAIOBjbLhA/132, createdBy=4b1e2361466, createdName=赵八爷, createdTime=Tue Nov 09 22:25:57 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053045, encodeId=a6ed105304527, content=正好需要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9615438799, createdName=ms5000001066050641, createdTime=Sun Sep 19 16:53:31 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962524, encodeId=8d08196252442, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 06 20:28:12 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082976, encodeId=c9c820829e637, content=<a href='/topic/show?id=422e50661bf' target=_blank style='color:#2F92EE;'>#微生物-肠-脑轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50661, encryptionId=422e50661bf, topicName=微生物-肠-脑轴)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Sun Feb 06 16:28:12 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996275, encodeId=e4589962e5cd, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2cd5528102, createdName=ms4000001358121555, createdTime=Mon Jul 05 00:25:14 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973413, encodeId=65a99e341314, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Jun 14 10:38:10 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967917, encodeId=291a96e917b5, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27355466082, createdName=ms4000000724907591, createdTime=Sun May 23 14:12:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967620, encodeId=64d696e62095, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/0456f89e128a46948e578a75312c8d3c/e466bb6c0b644e8196e18e045a30a0f0.jpg, createdBy=1c165082954, createdName=145b8a5bm09暂无昵称, createdTime=Fri May 21 22:53:15 CST 2021, time=2021-05-21, status=1, ipAttribution=)]
    2021-07-06 维他命

    #CEL#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1825281, encodeId=0ad7182528117, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jun 02 21:28:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872214, encodeId=025d18e22140b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jan 09 00:28:12 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068777, encodeId=4dd51068e771a, content=好东西 学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eodb9QgicrLYiaMpYYNrS5bh4l2oVxUu73PUHsbIQX0yYSN2SiaOaP7GBZbygWF0wQRAbaZAIOBjbLhA/132, createdBy=4b1e2361466, createdName=赵八爷, createdTime=Tue Nov 09 22:25:57 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053045, encodeId=a6ed105304527, content=正好需要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9615438799, createdName=ms5000001066050641, createdTime=Sun Sep 19 16:53:31 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962524, encodeId=8d08196252442, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 06 20:28:12 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082976, encodeId=c9c820829e637, content=<a href='/topic/show?id=422e50661bf' target=_blank style='color:#2F92EE;'>#微生物-肠-脑轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50661, encryptionId=422e50661bf, topicName=微生物-肠-脑轴)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Sun Feb 06 16:28:12 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996275, encodeId=e4589962e5cd, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2cd5528102, createdName=ms4000001358121555, createdTime=Mon Jul 05 00:25:14 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973413, encodeId=65a99e341314, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Jun 14 10:38:10 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967917, encodeId=291a96e917b5, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27355466082, createdName=ms4000000724907591, createdTime=Sun May 23 14:12:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967620, encodeId=64d696e62095, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/0456f89e128a46948e578a75312c8d3c/e466bb6c0b644e8196e18e045a30a0f0.jpg, createdBy=1c165082954, createdName=145b8a5bm09暂无昵称, createdTime=Fri May 21 22:53:15 CST 2021, time=2021-05-21, status=1, ipAttribution=)]
    2022-02-06 12498cb5m13暂无昵称

    #微生物-肠-脑轴#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1825281, encodeId=0ad7182528117, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jun 02 21:28:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872214, encodeId=025d18e22140b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jan 09 00:28:12 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068777, encodeId=4dd51068e771a, content=好东西 学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eodb9QgicrLYiaMpYYNrS5bh4l2oVxUu73PUHsbIQX0yYSN2SiaOaP7GBZbygWF0wQRAbaZAIOBjbLhA/132, createdBy=4b1e2361466, createdName=赵八爷, createdTime=Tue Nov 09 22:25:57 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053045, encodeId=a6ed105304527, content=正好需要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9615438799, createdName=ms5000001066050641, createdTime=Sun Sep 19 16:53:31 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962524, encodeId=8d08196252442, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 06 20:28:12 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082976, encodeId=c9c820829e637, content=<a href='/topic/show?id=422e50661bf' target=_blank style='color:#2F92EE;'>#微生物-肠-脑轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50661, encryptionId=422e50661bf, topicName=微生物-肠-脑轴)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Sun Feb 06 16:28:12 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996275, encodeId=e4589962e5cd, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2cd5528102, createdName=ms4000001358121555, createdTime=Mon Jul 05 00:25:14 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973413, encodeId=65a99e341314, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Jun 14 10:38:10 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967917, encodeId=291a96e917b5, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27355466082, createdName=ms4000000724907591, createdTime=Sun May 23 14:12:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967620, encodeId=64d696e62095, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/0456f89e128a46948e578a75312c8d3c/e466bb6c0b644e8196e18e045a30a0f0.jpg, createdBy=1c165082954, createdName=145b8a5bm09暂无昵称, createdTime=Fri May 21 22:53:15 CST 2021, time=2021-05-21, status=1, ipAttribution=)]
    2021-07-05 ms4000001358121555

    很不错的文章

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1825281, encodeId=0ad7182528117, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jun 02 21:28:12 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872214, encodeId=025d18e22140b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jan 09 00:28:12 CST 2022, time=2022-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068777, encodeId=4dd51068e771a, content=好东西 学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eodb9QgicrLYiaMpYYNrS5bh4l2oVxUu73PUHsbIQX0yYSN2SiaOaP7GBZbygWF0wQRAbaZAIOBjbLhA/132, createdBy=4b1e2361466, createdName=赵八爷, createdTime=Tue Nov 09 22:25:57 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053045, encodeId=a6ed105304527, content=正好需要这个, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9615438799, createdName=ms5000001066050641, createdTime=Sun Sep 19 16:53:31 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962524, encodeId=8d08196252442, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 06 20:28:12 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082976, encodeId=c9c820829e637, content=<a href='/topic/show?id=422e50661bf' target=_blank style='color:#2F92EE;'>#微生物-肠-脑轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50661, encryptionId=422e50661bf, topicName=微生物-肠-脑轴)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Sun Feb 06 16:28:12 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996275, encodeId=e4589962e5cd, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2cd5528102, createdName=ms4000001358121555, createdTime=Mon Jul 05 00:25:14 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973413, encodeId=65a99e341314, content=学习了 , beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=78f72514592, createdName=海1991, createdTime=Mon Jun 14 10:38:10 CST 2021, time=2021-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967917, encodeId=291a96e917b5, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=27355466082, createdName=ms4000000724907591, createdTime=Sun May 23 14:12:06 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967620, encodeId=64d696e62095, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/0456f89e128a46948e578a75312c8d3c/e466bb6c0b644e8196e18e045a30a0f0.jpg, createdBy=1c165082954, createdName=145b8a5bm09暂无昵称, createdTime=Fri May 21 22:53:15 CST 2021, time=2021-05-21, status=1, ipAttribution=)]
    2021-06-14 海1991

    学习了

    0

  9. 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    2021-05-23 ms4000000724907591

    学到了学到了

    0

  10. 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    2021-05-21 145b8a5bm09暂无昵称

    1

    0

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