Sci Rep:眼压升高对视神经乳头的血流变化研究

2018-12-10 MedSci MedSci原创

日本名古屋大学医学研究科眼科的Iwase T等人近日在Sci Rep发表了一篇重要的工作。目前对于由人工眼压升高(IOP)引起的眼灌注压(OPP)变化而引起的视神经乳头(ONH)血流变化过程尚不清楚。作者通过激光散斑流动图,计算ONH上的平均模糊率(MBR)来表征血流量情况。

日本名古屋大学医学研究科眼科的Iwase T等人近日在Sci Rep发表了一篇重要的工作。目前对于由人工眼压升高(IOP)引起的眼灌注压(OPP)变化而引起的视神经乳头(ONH)血流变化过程尚不清楚。作者通过激光散斑流动图,计算ONH上的平均模糊率(MBR)来表征血流量情况。

他们总共对27只健康眼睛进行了研究。通过眼科动力计,在眼睛上施加压力,分别在IOP升高20或30mmHg的前、中、后不同时段测量MBR。结果发现,IOP升高20mmHg后,MB-血管的降低百分比为-24.7%,MBR-组织的降低百分比为-16.0%(P <0.001)。对于IOP升高30mmHg组,MBR-血管的减少百分比为-35.3%,MBR-组织为-24.7%(P <0.001)。在IOP升高到30 mmHg的 10分钟期间,MBR-血管和MBR-组织在IOP开始升高后1分钟开始恢复到基线水平(分别为P <0.01,P <0.05),同时在眼压升高的10分钟内呈现持续返回状态(P <0.001,P <0.01)。

因此,他们得出结论,针对由IOP升高引起的OPP的变化,ONH可以自动调节其血流量来适应其变化。

原文出处:

Iwase, T., et al., Evaluation of optic nerve head blood flow in response to increase of intraocular pressure. Sci Rep, 2018. 8(1): p. 17235.

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    2019-03-29 gj0740
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    2018-12-12 swallow

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