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JCEM：亚临床甲状腺功能减退症和成年人抑郁症的相关性分析！

2018-02-04 xing.T MedSci原创

亚临床甲状腺功能减退症成年人抑郁症相关性
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由此可见，在这项包含中年男性和女性的大型前瞻性队列研究中，亚临床甲状腺功能减退症和抑郁症状发生之间没有明显的关联。

亚临床甲状腺功能减退症在抑郁症发生发展中的作用仍然存在争议。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员目的是评估亚临床甲状腺功能减退症与抑郁症状发生之间的前瞻性关联。

在2011年1月1日至2014年12月31日期间，研究人员对220545例未患抑郁症的且至少进行了两次全面体检的中年成人进行了前瞻性队列研究，研究人员采用电化学发光免疫法测定促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素(FT4）水平。该研究结局为抑郁症状的发生，定义为CES-D评分>16分。

在平均2年的随访期间，7323名参与者出现抑郁症状。亚临床甲状腺功能减退症患者与甲状腺功能正常者相比，发生抑郁症状的多元校正风险比（HR）为0.97（0.87-1.09）。同样地，在甲状腺功能正常参与者（n=87822）中，甲状腺激素水平与抑郁症状发生风险增加之间没有明显的相关性。

由此可见，在这项包含中年男性和女性的大型前瞻性队列研究中，亚临床甲状腺功能减退症和抑郁症状发生之间没有明显的关联。

原始出处：

Ji Sun Kim,et al. Subclinical hypothyroidism and incident depression in young and middle age adults.J Clin Endocrinol Metab. 2017. https://doi.org/10.1210/jc.2017-01247

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    2018-08-01 smallant2015

    #JCEM#

    0

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    2018-07-04 医者仁心

    #相关性#

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    2018-05-20 zhangmingxiang

    #临床甲状腺功能减退#

    0

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    2018-09-10 achengzhao

    #JCE#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1777762, encodeId=e8f21e7776262, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Aug 01 23:08:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837451, encodeId=3020183e45164, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jul 04 12:08:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797431, encodeId=47b01e9743109, content=<a href='/topic/show?id=b84c22894e2' target=_blank style='color:#2F92EE;'>#临床甲状腺功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22894, encryptionId=b84c22894e2, topicName=临床甲状腺功能减退)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Sun May 20 21:08:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063144, encodeId=63af2063144a1, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Sep 10 07:08:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285785, encodeId=343a285e857c, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Feb 06 23:56:52 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523596, encodeId=a37a1523596e9, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538186, encodeId=9279153818679, content=<a href='/topic/show?id=6a032421985' target=_blank style='color:#2F92EE;'>#亚临床甲状腺功能减退症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24219, encryptionId=6a032421985, topicName=亚临床甲状腺功能减退症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c34212938139, createdName=bsmagic9136, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285073, encodeId=eb582850e383, content=好文章.学习了.亚甲减, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 04 15:29:17 CST 2018, time=2018-02-04, status=1, ipAttribution=)]
    2018-02-06 天涯183

    非常好的文章.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777762, encodeId=e8f21e7776262, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Aug 01 23:08:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837451, encodeId=3020183e45164, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jul 04 12:08:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797431, encodeId=47b01e9743109, content=<a href='/topic/show?id=b84c22894e2' target=_blank style='color:#2F92EE;'>#临床甲状腺功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22894, encryptionId=b84c22894e2, topicName=临床甲状腺功能减退)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Sun May 20 21:08:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063144, encodeId=63af2063144a1, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Sep 10 07:08:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285785, encodeId=343a285e857c, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Feb 06 23:56:52 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523596, encodeId=a37a1523596e9, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538186, encodeId=9279153818679, content=<a href='/topic/show?id=6a032421985' target=_blank style='color:#2F92EE;'>#亚临床甲状腺功能减退症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24219, encryptionId=6a032421985, topicName=亚临床甲状腺功能减退症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c34212938139, createdName=bsmagic9136, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285073, encodeId=eb582850e383, content=好文章.学习了.亚甲减, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 04 15:29:17 CST 2018, time=2018-02-04, status=1, ipAttribution=)]
    2018-02-06 anminleiryan

    #相关性分析#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1777762, encodeId=e8f21e7776262, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Aug 01 23:08:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837451, encodeId=3020183e45164, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jul 04 12:08:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1797431, encodeId=47b01e9743109, content=<a href='/topic/show?id=b84c22894e2' target=_blank style='color:#2F92EE;'>#临床甲状腺功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22894, encryptionId=b84c22894e2, topicName=临床甲状腺功能减退)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Sun May 20 21:08:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063144, encodeId=63af2063144a1, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Sep 10 07:08:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285785, encodeId=343a285e857c, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Feb 06 23:56:52 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523596, encodeId=a37a1523596e9, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538186, encodeId=9279153818679, content=<a href='/topic/show?id=6a032421985' target=_blank style='color:#2F92EE;'>#亚临床甲状腺功能减退症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24219, encryptionId=6a032421985, topicName=亚临床甲状腺功能减退症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c34212938139, createdName=bsmagic9136, createdTime=Tue Feb 06 06:08:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285073, encodeId=eb582850e383, content=好文章.学习了.亚甲减, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 04 15:29:17 CST 2018, time=2018-02-04, status=1, ipAttribution=)]
    2018-02-06 bsmagic9136

    #亚临床甲状腺功能减退症#

    0

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    2018-02-04 1e0f8808m18(暂无匿称)

    好文章.学习了.亚甲减

    0