IBD: 早期出现关节炎与免疫抑制药物的失效与小儿克罗恩病严重程度有关

2018-10-21 MedSci MedSci原创

克罗恩病(CD)是一种慢性反复发作的炎症性疾病。为了优化治疗,能否早期预测疾病严重程度显得尤为重要。本研究的目的是评估关节炎与儿童CD使用免疫抑制剂治疗失败之间的联系。

背景
克罗恩病(CD)是一种慢性反复发作的炎症性疾病。为了优化治疗,能否早期预测疾病严重程度显得尤为重要。本研究的目的是评估关节炎与儿童CD使用免疫抑制剂治疗失败之间的联系。

方法
研究人员前瞻性收集了年龄小于17岁并且在2005年至2014年期间确诊CD的儿童及青少年患者。主要观察结果是CD诊断后2年内至少有1例免疫抑制药物治疗失败的患者百分比,采用倾向评分模型进行数据分析。

结果
本项研究共纳入了272名CD患者。中位年龄为12.1岁。65名患者(23.9%)患有关节炎,且主要发生在CD诊断后的第一年。研究人员发现2年后关节炎与免疫抑制药物治疗失败之间存在极显着的相关性(OR = 6.9; 95%[CI],2.7-18.0;P<0.0001)。关节炎也与诊断后2年因肠道疾病引入生物制剂显着相关(OR = 3.2,95%CI,1.8-6.0;P= 0.0001)。

结论
关节炎与儿童CD的免疫抑制治疗失败密切相关。在疾病早期发生关节炎可能是更密切的随访或特定治疗表征。

原始出处:

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    2018-10-28 小爱医生

    学习了

    0

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    2018-10-23 bnurmamat
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    2018-10-22 kafei

    学习了谢谢

    0

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