IBD: 早期出现关节炎与免疫抑制药物的失效与小儿克罗恩病严重程度有关

2018-10-21 MedSci MedSci原创

克罗恩病(CD)是一种慢性反复发作的炎症性疾病。为了优化治疗,能否早期预测疾病严重程度显得尤为重要。本研究的目的是评估关节炎与儿童CD使用免疫抑制剂治疗失败之间的联系。

背景
克罗恩病(CD)是一种慢性反复发作的炎症性疾病。为了优化治疗,能否早期预测疾病严重程度显得尤为重要。本研究的目的是评估关节炎与儿童CD使用免疫抑制剂治疗失败之间的联系。

方法
研究人员前瞻性收集了年龄小于17岁并且在2005年至2014年期间确诊CD的儿童及青少年患者。主要观察结果是CD诊断后2年内至少有1例免疫抑制药物治疗失败的患者百分比,采用倾向评分模型进行数据分析。

结果
本项研究共纳入了272名CD患者。中位年龄为12.1岁。65名患者(23.9%)患有关节炎,且主要发生在CD诊断后的第一年。研究人员发现2年后关节炎与免疫抑制药物治疗失败之间存在极显着的相关性(OR = 6.9; 95%[CI],2.7-18.0;P<0.0001)。关节炎也与诊断后2年因肠道疾病引入生物制剂显着相关(OR = 3.2,95%CI,1.8-6.0;P= 0.0001)。

结论
关节炎与儿童CD的免疫抑制治疗失败密切相关。在疾病早期发生关节炎可能是更密切的随访或特定治疗表征。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2035694, encodeId=0233203569420, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri Nov 23 01:25:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350706, encodeId=11cb350e06be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/oCx7GX9P4w4pfwbrTqlz3AKKBmbmWLPColfBc1VftJ3aB7cKVjicpgWUeWHicYyiattXKQB98X6CC2sZ8U17kg2Rw/132, createdBy=2a042430628, createdName=小爱医生, createdTime=Sun Oct 28 00:35:05 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263489, encodeId=4d201263489b2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265826, encodeId=89531265826f0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350145, encodeId=d73235014587, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:14:58 CST 2018, time=2018-10-22, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2035694, encodeId=0233203569420, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri Nov 23 01:25:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350706, encodeId=11cb350e06be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/oCx7GX9P4w4pfwbrTqlz3AKKBmbmWLPColfBc1VftJ3aB7cKVjicpgWUeWHicYyiattXKQB98X6CC2sZ8U17kg2Rw/132, createdBy=2a042430628, createdName=小爱医生, createdTime=Sun Oct 28 00:35:05 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263489, encodeId=4d201263489b2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265826, encodeId=89531265826f0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350145, encodeId=d73235014587, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:14:58 CST 2018, time=2018-10-22, status=1, ipAttribution=)]
    2018-10-28 小爱医生

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2035694, encodeId=0233203569420, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri Nov 23 01:25:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350706, encodeId=11cb350e06be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/oCx7GX9P4w4pfwbrTqlz3AKKBmbmWLPColfBc1VftJ3aB7cKVjicpgWUeWHicYyiattXKQB98X6CC2sZ8U17kg2Rw/132, createdBy=2a042430628, createdName=小爱医生, createdTime=Sun Oct 28 00:35:05 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263489, encodeId=4d201263489b2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265826, encodeId=89531265826f0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350145, encodeId=d73235014587, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:14:58 CST 2018, time=2018-10-22, status=1, ipAttribution=)]
    2018-10-23 bnurmamat
  4. [GetPortalCommentsPageByObjectIdResponse(id=2035694, encodeId=0233203569420, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri Nov 23 01:25:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350706, encodeId=11cb350e06be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/oCx7GX9P4w4pfwbrTqlz3AKKBmbmWLPColfBc1VftJ3aB7cKVjicpgWUeWHicYyiattXKQB98X6CC2sZ8U17kg2Rw/132, createdBy=2a042430628, createdName=小爱医生, createdTime=Sun Oct 28 00:35:05 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263489, encodeId=4d201263489b2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265826, encodeId=89531265826f0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350145, encodeId=d73235014587, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:14:58 CST 2018, time=2018-10-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2035694, encodeId=0233203569420, content=<a href='/topic/show?id=8873468e8a8' target=_blank style='color:#2F92EE;'>#小儿克罗恩病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46878, encryptionId=8873468e8a8, topicName=小儿克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Fri Nov 23 01:25:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350706, encodeId=11cb350e06be, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/oCx7GX9P4w4pfwbrTqlz3AKKBmbmWLPColfBc1VftJ3aB7cKVjicpgWUeWHicYyiattXKQB98X6CC2sZ8U17kg2Rw/132, createdBy=2a042430628, createdName=小爱医生, createdTime=Sun Oct 28 00:35:05 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263489, encodeId=4d201263489b2, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265826, encodeId=89531265826f0, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Oct 23 11:25:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350145, encodeId=d73235014587, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Oct 22 10:14:58 CST 2018, time=2018-10-22, status=1, ipAttribution=)]
    2018-10-22 kafei

    学习了谢谢

    0

相关资讯

Arthritis Rheumatol:类风湿关节炎患者胰岛素抵抗增加

类风湿关节炎(RA)患者具有胰岛素抵抗(IR)升高现象,但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联,相关研究刊登在Arthritis & Rheumatology杂志上。 哥伦比亚大学Jon T. Giles,MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况,使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度,HOMA-I

A&R:骨关节炎患者的松质骨抗疲劳损伤性能优于骨质疏松症患者

髋关节骨关节炎(OA)和骨质疏松症(OP)很少发生在同一个患者身上,故OA和OP的软骨下松质骨可能存在较大差别。因此,来自上海交通大学的李展春博士等人进行了一项研究,研究结果发表于2012年12月的《关节炎与风湿病》(ARTHRITIS & RHEUMATISM)杂志上。作者发现因骨量和骨结构不同,OA和OP的松质骨机械性能存在明显差异。 此研究目的在于确定这两种情况是否与软骨下松质骨的