J Dermatolog Treat:氨纶治疗慢性自发性荨麻疹和其他皮肤病患者瘙痒症的疗效

2020-06-25 MedSci原创 MedSci原创

本研究旨在评估比拉斯汀在慢性自发性荨麻疹(CSU)或其他瘙痒性皮肤病患者中缓解瘙痒的有效性/安全性。

本研究旨在评估比拉斯汀在慢性自发性荨麻疹(CSU)或其他瘙痒性皮肤病患者中缓解瘙痒的有效性/安全性。

 

在这项多中心、开放标签、探索性研究中(EudraCT编号:2016-001505-17),115名患有CSU(n = 34)、湿疹/皮炎(n = 30)、瘙痒症(n = 25)或皮肤瘙痒症(n = 26)的成人,接受比拉斯汀20 mg,每天一次,持续8周,或者对于无反应的患者(第2周瘙痒症评分改善<30%),从第2周开始,每天40 mg。

 

结果显示,使用比拉斯汀后,从基线到第8周(主要终点)每周瘙痒严重程度评分的平均变化减少(总体和各疾病组);总体上,百分比和绝对减少分别为71.16%和1.63点(P < .001)。更新的非应答者(n = 31)从基线到第8周的每周瘙痒严重程度评分得到改善;百分比和绝对减少分别为49.08%和1.13点(p < .001)。毕拉斯汀改善了所有疾病组在第4周和第8周的皮肤科生活质量指数(p < .001),以及CSU患者的7天荨麻疹活动评分(p < .001)。毕司汀的耐受性良好。

 

总之,该研究结果表明,毕拉斯汀可缓解荨麻疹和其他皮肤病相关的瘙痒,具有非常好的安全性。

 

原始出处:

 

Esther Serra, Cristina Campo, et al., Efficacy and Safety of Bilastine in Reducing Pruritus in Patients With Chronic Spontaneous Urticaria and Other Skin Diseases: An Exploratory Study. J Dermatolog Treat. 2020 May;31(3):270-278. doi: 10.1080/09546634.2019.1590522.

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    2020-06-27 listen318
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    2020-06-27 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1826142, encodeId=9759182614280, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 06 01:07:37 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796273, encodeId=a4341e9627338, content=<a href='/topic/show?id=cf2a1e7818c' target=_blank style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sat Jun 05 07:07:37 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302581, encodeId=43fd1302581e1, content=<a href='/topic/show?id=b541e1219dc' target=_blank style='color:#2F92EE;'>#瘙痒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71219, encryptionId=b541e1219dc, topicName=瘙痒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355591, encodeId=461b135559134, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378792, encodeId=586613e8792cd, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402911, encodeId=ca291402911b0, content=<a href='/topic/show?id=6103e12204a' target=_blank style='color:#2F92EE;'>#瘙痒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71220, encryptionId=6103e12204a, topicName=瘙痒症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6f82431450, createdName=lvygwyt2782, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530616, encodeId=6edd153061690, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032553, encodeId=66d810325535d, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Jun 26 00:07:37 CST 2020, time=2020-06-26, status=1, ipAttribution=)]
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1826142, encodeId=9759182614280, content=<a href='/topic/show?id=f6a6e206066' target=_blank style='color:#2F92EE;'>#皮肤病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72060, encryptionId=f6a6e206066, topicName=皮肤病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 06 01:07:37 CST 2020, time=2020-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796273, encodeId=a4341e9627338, content=<a href='/topic/show?id=cf2a1e7818c' target=_blank style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sat Jun 05 07:07:37 CST 2021, time=2021-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302581, encodeId=43fd1302581e1, content=<a href='/topic/show?id=b541e1219dc' target=_blank style='color:#2F92EE;'>#瘙痒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71219, encryptionId=b541e1219dc, topicName=瘙痒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355591, encodeId=461b135559134, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378792, encodeId=586613e8792cd, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402911, encodeId=ca291402911b0, content=<a href='/topic/show?id=6103e12204a' target=_blank style='color:#2F92EE;'>#瘙痒症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71220, encryptionId=6103e12204a, topicName=瘙痒症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6f82431450, createdName=lvygwyt2782, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530616, encodeId=6edd153061690, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Sat Jun 27 12:07:37 CST 2020, time=2020-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032553, encodeId=66d810325535d, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Fri Jun 26 00:07:37 CST 2020, time=2020-06-26, status=1, ipAttribution=)]
    2020-06-27 sodoo
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    2020-06-26 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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