Front.aging-neurosci-正常老化大脑中局部脑葡萄糖代谢的性别相关差异

2022-02-17 brainnew神内神外 网络

衰老会导致大脑功能和结构发生变化,例如认知能力下降,研究表明大脑衰老可能在神经退行性变的初始阶段发生。

 

衰老会导致大脑功能和结构发生变化,例如认知能力下降研究表明大脑衰老可能神经退行性变的初始阶段发生。人类生物学的一个重要特征是,在几乎所有国家中,女性的寿命都比男性长。为了检测不同性别患者的临床前疾病发展阶段,需要捕捉到偏离健康状态的细微异常重要的是事先了解不同性别样本健康的大脑形态和活动

 

正电子发射断层扫描(Positron Emission Tomography,PET)脑成像是一种功能性神经影像学方法,可以无创地反映体内葡萄糖代谢情况。一项使用 FDG-PET 的早期研究表明,女性的整体脑葡萄糖代谢率高于男性。先前的一项研究表明,大脑结构和新陈代谢的一些与年龄相关的变化与年龄呈非线性关系,并且在老年人中表现出不均等的加速变化。然而,关于衰老大脑中局部脑葡萄糖代谢的性别相关差异的研究却鲜有报道。所以来自宁夏医科大学总医院的研究团队使用 FDG- PET/CT 检查了不同性别健康受试者的脑葡萄糖代谢变化,并讨论了性别之间的代谢差异和与年龄相关的脑衰老之间的关系。

 

 

研究结果

 

1、受试者特征

作者招募了344名健康志愿者,其中男性217名,女性127名(年龄范围:40-89岁)。所有受试者均接受氟-18 氟脱氧葡萄糖(18F-FDG) 正电子发射断层扫描 (PET)。将所有数据分为四组每位参与者都经过 PET、MR 和其他检查仔细筛选,以排除异常,例如神经退行性或精神疾病、酒精/虐待、脑血管疾病、糖尿病和甲状腺功能亢进等代谢疾病以及其他全身性恶性肿瘤。40~50岁组为基线组采用统计参数映射(SPM)分析来说明组间的差异,见表1。

表1 受试者特征

 

2、男性和女性的脑代谢变化不一致

研究表明,女性小脑的代谢明显下降,而男性则没有。小脑是衰老研究中一个重要但未被充分研究的区域在运动和认知行为中都起作用。在本研究中,双侧额叶代谢的下降开始于男性60岁组和女性70岁组。一些学者认为,这可能是由于男性的酒精摄入量高于女性梭状回 (FG; BA 18) 通常属于颞叶的一部分,被认为是高级视觉功能专业计算的关键结构,例如面部感知、物体识别和阅读。在这项研究中,发现FG随着年龄的增长而显着下降 60 岁女性新陈代谢下降最明显的大脑区域。此外,研究发现70岁男性组的前扣带回代谢明显下降。

图1 男性脑代谢变化区域

图2 女性脑区域变化情况

 

3、男性和女性之前的代谢差异

作者发现男性60岁组和70岁组尾状核区脑代谢均有不同程度下降,而女性60岁组枕部出现特异性下降的脑区。在男性和女性受试者中,与年龄相关的增加的 FDG 摄取区域明显不同。

表2 女性新城代谢下降脑区

表3 女性新陈代谢增加脑区

表4 男性新陈代谢降低脑区

表5 男性新陈代谢增加脑区

 

4、随年龄增长的代谢变化趋势

以往文献表明男女脑代谢变化趋势存在一定差异。在作者的研究中,发现男性的脑老化从60岁开始,70岁以后表现更多,而女性的脑老化从60岁开始,70岁比60岁老化程度小。这些数据表明,女性的衰老速度可能比男性慢。这种情况可能与激素水平有关,研究表明,雌激素与情绪控制、脑血管和神经元的保护作用有一定的相关性,使用雌激素替代疗法可以降低女性患AD的风险。

综上,从作者的研究中可以得到以下几个结论:(1)从60岁开始发现受试者脑代谢明显下降,尤其是双侧额叶、双侧颞叶和扣带回下回,无论性别如何;(2) 作者发现了性别之间特定的脑代谢差异,包括男性的尾状核区域和女性的枕叶区域;(3) 不同性别的老龄化趋势不同。

 

但是作者的研究也存在一些局限性,主要限制是样本数量,后期需要扩大样本数量进行更为细致的研究。其二人脑的老化是变化的,在作者的研究中,数据是40岁开始收集的,未得到40岁之前大脑代谢的变化数据和变化趋势,需要收集40岁前和 80 岁后的样本进行进一步的研究。

 

参考文献

 

Bei Feng, Jiang Cao, YaPing Yu, HaiYan Yang, YangHongYan Jiang, Ying Liu, Rong Wang and Qian Zhao,Gender-Related Differences in Regional Cerebral Glucose Metabolism in Normal Aging Brain,Front. Aging Neurosci., 10 February 2022 ,https://doi.org/10.3389/fnagi.2022.809767

 

编译作者:  原代美少女 (Brainnews创作团队) 

校审: Simon (Brainnews编辑部)

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    2022-02-19 zz70
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    2022-02-19 仁者大医
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    2022-02-19 chg122
  5. [GetPortalCommentsPageByObjectIdResponse(id=1360632, encodeId=dabb1360632e7, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364781, encodeId=5d4e1364e81fd, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388061, encodeId=6fb4138806109, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406159, encodeId=cc7a1406159da, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553662, encodeId=2ef11553662f8, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194516, encodeId=08f311945166c, content=期待进一步研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Feb 17 17:41:05 CST 2022, time=2022-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194435, encodeId=b55b1194435ff, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Thu Feb 17 14:37:56 CST 2022, time=2022-02-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1360632, encodeId=dabb1360632e7, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364781, encodeId=5d4e1364e81fd, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388061, encodeId=6fb4138806109, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406159, encodeId=cc7a1406159da, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553662, encodeId=2ef11553662f8, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194516, encodeId=08f311945166c, content=期待进一步研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Feb 17 17:41:05 CST 2022, time=2022-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194435, encodeId=b55b1194435ff, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Thu Feb 17 14:37:56 CST 2022, time=2022-02-17, status=1, ipAttribution=)]
    2022-02-17 carrotlyl

    期待进一步研究成果

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1360632, encodeId=dabb1360632e7, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364781, encodeId=5d4e1364e81fd, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388061, encodeId=6fb4138806109, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406159, encodeId=cc7a1406159da, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553662, encodeId=2ef11553662f8, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Sat Feb 19 02:11:52 CST 2022, time=2022-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194516, encodeId=08f311945166c, content=期待进一步研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Feb 17 17:41:05 CST 2022, time=2022-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194435, encodeId=b55b1194435ff, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Thu Feb 17 14:37:56 CST 2022, time=2022-02-17, status=1, ipAttribution=)]
    2022-02-17 yangchou

    好文章,谢谢分享。

    0

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现在00后已经开始自嘲“老阿姨”了,“95后的初老症状”也引起了一番热议。出现第一道皱纹、稍微熬夜就疲累、记忆力下降、体重增加、跑几步就喘气……2020年新氧联合第一财经发布的《新青年抗衰老调查报告》

Rejuvenation Research:这名科学家有点狠!把自己当“小白鼠”以身试药试图逆转衰老

长生不老是人类几千年来的梦想,无数人为之进行了各种尝试。近日,美国的一名科学家就把自己当做“小白鼠”,以身试药,试图破解自身的基因密码,逆转衰老!

Nature:白凡/黄岩谊团队与合作者揭示人体正常组织体细胞突变和衰老规律

人体内各种正常组织中细胞都在不可避免地积累突变。这些体细胞突变(somatic mutation)的发生通常与细胞活动中遭受的各类DNA损伤和细胞分裂过程中DNA的复制错误没有得到(正确的)修复相关。

Aging Cell:运动不怕晚!即使晚年才开始锻炼,也可以减缓衰老

衰老,是一个复杂、多阶段、渐进的过程,发生在生命的整个过程。一个常见的衰老标志是,细胞慢慢失去产生新的健康细胞来修复损伤的能力。

Nature:核糖体停顿+蛋白质失衡,时间这把“杀猪刀”!

这项研究将衰老过程中的核糖体停顿与共翻译转运、蛋白质稳态联系起来,证明了然停顿的增加将导致RQC超负荷新生多肽聚集,破坏蛋白质稳态,在衰老引起的全身衰退中起重要作用。

Cell Discovery:刘光慧等团队发现抗衰老关键代谢物——尿苷

2月1日,《细胞发现》上发表了我国科学家的研究,通过对包括鹿茸干细胞在内的多种细胞进行代谢层面的分子图谱绘制,寻找究竟是什么样的生命活性物质让鹿茸有再生的能力。