NAT MED:多囊卵巢综合征是如何遗传的?

2018-05-17 海北 MedSci原创

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是全球女性不孕的主要原因,并伴有高度的合并症和经济负担。 至今为止,PCOS如何从一代传到下一代尚不清楚,但这可能是一个发育问题。

多囊卵巢综合征(polycystic ovary syndromePCOS)是全球女性不孕的主要原因,并伴有高度的合并症和经济负担。 至今为止,PCOS如何从一代传到下一代尚不清楚,但这可能是一个发育问题。

与健康女性相比,大多数PCOS妇女表现出较高水平的循环黄体生成素,表明促性腺激素释放激素(GnRH)和抗苗勒氏激素(AMH)释放增加。子宫内过多的AMH可能会影响女性胎儿的发育。然而,在女性正常生育期间,随着妊娠,AMH水平会有所下降,但目前还不清楚在PCOS孕妇中,AMH是否也有所升高。

最近,来自法国的研究人员测量了一群PCOS孕妇和对照孕妇的AMH,发现前者与后者相比AMH显着升高。为了确定PCOS妇女妊娠期间AMH的升高是旁观者效应还是后代状况的驱动因素,研究人员通过用AMH治疗怀孕小鼠来模拟其临床发现,并且在出生后测试其雌性后代的神经内分泌表型。

研究人员发现,AMH处理会导致母体神经内分泌驱动的睾酮过量,减少胎盘将睾酮代谢为雌二醇,导致暴露的雌性胎儿的男性化,以及成年期的PCOS样生殖和神经内分泌表型。研究人员发现受影响的雌性持续存在过度激活的GnRH神经元。在成年雌性后代中使用GnRH拮抗剂治疗能够将它们的神经内分泌表型恢复到正常状态。

这些研究结果突出显示了过量产前AMH暴露和随后的异常GnRH受体信号在PCOS患者的神经内分泌功能障碍中的关键作用,同时为成年期治疗该病症提供了新的潜在治疗途径。


原始出处:

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    2018-06-27 jyzxjiangqin

    多囊卵巢综合征是如何遗传的.

    0

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    2018-06-08 沙漠浪人

    遗传多囊卵巢综合征

    0

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    2018-09-28 heli0118
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    2018-05-23 沙漠浪人

    多囊卵巢综合征与遗传的关系

    0

  6. 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    2018-05-23 秀红

    学习了

    0

  7. 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    2018-05-20 易水河

    学习学习

    0

  8. 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    2018-05-20 溜溜梅不酸

    学习

    0

  9. 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    2018-05-19 yfjms

    学习

    0

  10. 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    2018-05-18 zhouqu_8

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多囊卵巢综合征(polycystic ovary syndrome,PCOS)又称Stein-Leventhal综合征,由Stein和Leventhal于1935年首次报道,是由遗传和环境因素共同导致的常见内分泌代谢疾病。在育龄妇女中,其患病率约为5%~10%,常见的临床表现为月经异常、不孕、高雄激素血征、卵巢多囊样表现等,可伴有肥胖、胰岛素抵抗、血脂紊乱等代谢异常,是2型糖尿病、心脑血管疾病和子

JCEM:二甲双胍用于多囊卵巢综合征妊娠治疗增加4岁子代超重风险!

由此可见,二甲双胍暴露的儿童体重指数较高,4岁时超重/肥胖患病率增加。

J Periodontol:慢性牙周炎和多囊卵巢综合征患者氧化状态研究

在多囊卵巢综合征(PCOS)中,血清和唾液8-羟基-2'-脱氧鸟苷(8-OHdG)和丙二醛(MDA)升高和血清总抗氧化状态(TAS)水平下降,慢性牙周炎(CP)患者的氧化应激(OS)水平增加。本研究的目的是研究CP和PCOS女性与健康女性相比,唾液和血清8-OHdG和MDA水平以及总抗氧化状态(TAS)。