JACC:外周动脉疾病合并糖尿病患者发生心血管疾病风险更高

2018-12-23 MedSci MedSci原创

糖尿病可以增加动脉粥样硬化心血管疾病的风险,但是目前对糖尿病给有症状的外周动脉疾病(PAD)患者带来心血管和肢体事件的独立风险知之甚少。本研究的目的旨在比较和评估PAD患者和PAD合并糖尿病患者发生心血管和肢体疾病的风险。本研究纳入了EUCLID临床试验中13885名有症状的PAD患者,主要终点事件是主要不良心血管事件(MACE)(心源性死亡、心梗和缺血性卒中),并分析比较了有糖尿病亚组和无糖尿病

糖尿病可以增加动脉粥样硬化血管疾病的风险,但是目前对糖尿病给有症状的外周动脉疾病(PAD)患者带来血管和肢体事件的独立风险知之甚少。本研究的目的旨在比较和评估PAD患者和PAD合并糖尿病患者发生心血管和肢体疾病的风险。

本研究纳入了EUCLID临床试验中13885名有症状的PAD患者,主要终点事件是主要不良心血管事件(MACE)(心源性死亡、心梗和缺血性卒中),并分析比较了有糖尿病亚组和无糖尿病亚组的患者。经过平均30个月时间的随访,有5354名患者有糖尿病(38.5%),其中96.1%为2型糖尿病,主要终点事件的发生率在PAD合并糖尿病患者中是15.9%,而在无糖尿病的PAD患者中发生率是10.4%(HR:.56; 95% [CI]: 1.41 - 1.72; p< 0.001)。另外,糖化血红蛋白每增加1%,MACE的风险就增加14.2%(95% CI: 1.09 - 1.20; p<0.0001)。

研究结果显示,外周动脉疾病合并糖尿病患者发生心血管和肢体缺血疾病的风险较高,糖化血红蛋白每增加1%,MACE的风险就增加14.2%。

原始出处:

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    2019-07-15 hbwxf
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    2019-01-03 zwjnj2

    努力学习认真的学习

    0

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    2018-12-28 orangesking

    看看

    0

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    2018-12-24 玻璃夕阳chen

    学习了

    0

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    2018-12-24 1521f35d1em

    受教了

    0

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