Am J Gastroenterol:入院时红细胞压积和血尿素氮预测重症急性胰腺炎

2016-01-24 Mechront 译 MedSci原创

对重症急性胰腺炎(AP)的预测仍然是一个挑战。研究者进行了一项研究,比较入院时血尿素氮(BUN)、红细胞压积、血肌酐水平,以及24h后这些值的变化,以确定预测持续的器官衰竭和胰腺坏死的最准确的实验室检测指标。该研究从三个独立队列中纳入了1612名AP患者。通过AUC分析评估以上实验室指标预测重症AP的准确性。汇总分析其对持续性器官衰竭和胰腺坏死风险的影响。最后选出最准确的实验室指标。研究数据显示,

对重症急性胰腺炎(AP)的预测仍然是一个挑战。研究者进行了一项研究,比较入院时血尿素氮(BUN)、红细胞压积、血肌酐水平,以及24h后这些值的变化,以确定预测持续的器官衰竭和胰腺坏死的最准确的实验室检测指标。

该研究从三个独立队列中纳入了1612名AP患者。通过AUC分析评估以上实验室指标预测重症AP的准确性。汇总分析其对持续性器官衰竭和胰腺坏死风险的影响。最后选出最准确的实验室指标。

研究数据显示,入院时红细胞比容≥44%和BUN在24h上升能最准确的预测器官衰竭 (AUC分别为: 0.67、0.71) 和胰腺坏死 (AUC分别为:0.66、0.67),这两个值优于其他实验室指标和急性生理和慢性健康评估II评分。汇总分析结果显示,入院时红细胞比容≥44%和BUN在24h上升预测持续性器官衰竭的OR值分别为3.54和5.84,预测胰腺坏死的OR分别为3.11和4.07。此外患者入院时如果红细胞比容≥44%和BUN在24h上升,那么持续性器官衰竭和胰腺坏死比率可达53.6%和60.3%。

研究结果表明,现有的实验室指标和评分系统间,入院时血细胞比容≥44%和BUN在24h上升可能在临床实践中的最优预测指标。

原始出处:

Koutroumpakis E, Wu BU,et al.Admission Hematocrit and Rise in Blood Urea Nitrogen at 24 h Outperform other Laboratory Markers in Predicting Persistent Organ Failure and Pancreatic Necrosis in Acute Pancreatitis: A Post Hoc Analysis of Three Large Prospective Databases.Am J Gastroenterol. 2015 


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    2016-02-17 xre2008
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1710828, encodeId=17291e10828e0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jul 27 00:25:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063938, encodeId=06e3206393854, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sat Feb 20 13:25:00 CST 2016, time=2016-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018511, encodeId=e3b8201851116, content=<a href='/topic/show?id=fb064e49519' target=_blank style='color:#2F92EE;'>#尿素氮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47495, encryptionId=fb064e49519, topicName=尿素氮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Wed Feb 17 13:25:00 CST 2016, time=2016-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941919, encodeId=358f194191984, content=<a href='/topic/show?id=774a95943de' target=_blank style='color:#2F92EE;'>#重症急性胰腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95943, encryptionId=774a95943de, topicName=重症急性胰腺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Tue Nov 29 21:25:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81678, encodeId=15d5816e831, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81686, encodeId=37238168666, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81679, encodeId=d241816e948, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81680, encodeId=f1c78168032, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81681, encodeId=00908168183, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81684, encodeId=fb6f816847a, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=)]
    2016-04-23 忠诚向上

    好好看看学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1710828, encodeId=17291e10828e0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jul 27 00:25:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063938, encodeId=06e3206393854, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sat Feb 20 13:25:00 CST 2016, time=2016-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018511, encodeId=e3b8201851116, content=<a href='/topic/show?id=fb064e49519' target=_blank style='color:#2F92EE;'>#尿素氮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47495, encryptionId=fb064e49519, topicName=尿素氮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Wed Feb 17 13:25:00 CST 2016, time=2016-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941919, encodeId=358f194191984, content=<a href='/topic/show?id=774a95943de' target=_blank style='color:#2F92EE;'>#重症急性胰腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95943, encryptionId=774a95943de, topicName=重症急性胰腺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Tue Nov 29 21:25:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81678, encodeId=15d5816e831, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81686, encodeId=37238168666, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81679, encodeId=d241816e948, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81680, encodeId=f1c78168032, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81681, encodeId=00908168183, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81684, encodeId=fb6f816847a, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=)]
    2016-04-23 忠诚向上

    好好看看学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1710828, encodeId=17291e10828e0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jul 27 00:25:00 CST 2016, time=2016-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063938, encodeId=06e3206393854, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sat Feb 20 13:25:00 CST 2016, time=2016-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018511, encodeId=e3b8201851116, content=<a href='/topic/show?id=fb064e49519' target=_blank style='color:#2F92EE;'>#尿素氮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47495, encryptionId=fb064e49519, topicName=尿素氮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Wed Feb 17 13:25:00 CST 2016, time=2016-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941919, encodeId=358f194191984, content=<a href='/topic/show?id=774a95943de' target=_blank style='color:#2F92EE;'>#重症急性胰腺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95943, encryptionId=774a95943de, topicName=重症急性胰腺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Tue Nov 29 21:25:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81678, encodeId=15d5816e831, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81686, encodeId=37238168666, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81679, encodeId=d241816e948, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81680, encodeId=f1c78168032, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81681, encodeId=00908168183, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=81684, encodeId=fb6f816847a, content=好好看看学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Apr 23 07:30:00 CST 2016, time=2016-04-23, status=1, ipAttribution=)]
    2016-04-23 忠诚向上

    好好看看学习

    0

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    2016-04-23 忠诚向上

    好好看看学习

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    2016-04-23 忠诚向上

    好好看看学习

    0

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    2016-04-23 忠诚向上

    好好看看学习

    0

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