Am J Clin Nutr:神奇,心血管状况可决定我们的咖啡因摄入量!

2021-03-15 MedSci原创 MedSci原创

你一天喝几杯咖啡?

过量饮用咖啡会导致不愉快的血管症状,如心动过速和心悸。这些令人不快的副作用通常都是咖啡的主要成分咖啡因造成的;众所周知,咖啡因还可引发一些列生理效应。此外,据研究,咖啡因还可短期内升高血压。但是在观察性研究中,习惯性饮用咖啡通常与血压无关或呈逆相关性。

到底是饮用咖啡影响了心血管症状,还是心血管症状会潜在影响饮用咖啡的习惯?

Elina等人开展了一项研究,旨在调查心血管症状是否会导致咖啡消费习惯的改变。研究结果于近日发表在《美国临床营养学》“Am J Clin Nutr”上。

研究人员采用了来自英国生物库的390435名欧洲血统参与者的信息,年龄在39-73岁之间。自我报告习惯喝咖啡,并在基线上测量收缩压(SBP)、舒张压(DBP)和心率。基线时的心血管症状基于医院诊断、保健记录和/或自我报告。

不同性别、年龄、心血管疾病和一般健康因素个体的咖啡摄入量

与没有报告心血管相关症状的参与者相比,患有原发性高血压、心绞痛或心律失常的参与者更可能饮用的较少量的含咖啡因的咖啡,而且可能不习惯性喝咖啡,或者喝去咖啡因的咖啡(P≤3.5×10-8)。

收缩压、舒张压和心率对咖啡因摄入量的影响

较高的收缩压和舒张压与基线时较低的含咖啡因咖啡消费量相关,并有一致的遗传证据支持所有方法的因果解释[MR-Egger回归β:收缩压每升高10 mmHg,咖啡饮用量减少0.21杯/天;舒张压每升高10 mmHg,咖啡饮用量减少0.33杯/天]。在遗传分析中,静息心率越高,喝无咖啡因咖啡的几率越大(MREggr OR:1.71)。

总而言之,该研究提供了心血管系统驱动的影响咖啡摄入量习惯的因果遗传学证据,表明人们会自然而然的根据自身的血压水平和心率调节咖啡摄入量。

原始出处:

Hypponen Elina,Zhou Ang,Cardiovascular symptoms affect the patterns of habitual coffee consumption.[J] .Am J Clin Nutr, 2021, 10.1093/ajcn/nqab014

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    2021-08-31 lmm397
  2. [GetPortalCommentsPageByObjectIdResponse(id=1860690, encodeId=6410186069049, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Aug 31 04:30:57 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263950, encodeId=0929126395035, content=<a href='/topic/show?id=62c239e74f2' target=_blank style='color:#2F92EE;'>#咖啡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39774, encryptionId=62c239e74f2, topicName=咖啡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=316c73, createdName=caoliehu, createdTime=Wed Mar 17 06:30:57 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948831, encodeId=fe3894883117, content=这都能研究? , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210226/f23705539a22465dad49b185641246f4/269e005bb68348558ceb01a4a8056073.jpg, createdBy=a54d5390453, createdName=T2DM终结者, createdTime=Tue Mar 16 22:07:26 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948389, encodeId=ddeb94838991, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Mar 15 16:01:27 CST 2021, time=2021-03-15, status=1, ipAttribution=)]
    2021-03-17 caoliehu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1860690, encodeId=6410186069049, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Aug 31 04:30:57 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263950, encodeId=0929126395035, content=<a href='/topic/show?id=62c239e74f2' target=_blank style='color:#2F92EE;'>#咖啡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39774, encryptionId=62c239e74f2, topicName=咖啡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=316c73, createdName=caoliehu, createdTime=Wed Mar 17 06:30:57 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948831, encodeId=fe3894883117, content=这都能研究? , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210226/f23705539a22465dad49b185641246f4/269e005bb68348558ceb01a4a8056073.jpg, createdBy=a54d5390453, createdName=T2DM终结者, createdTime=Tue Mar 16 22:07:26 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948389, encodeId=ddeb94838991, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Mar 15 16:01:27 CST 2021, time=2021-03-15, status=1, ipAttribution=)]
    2021-03-16 T2DM终结者

    这都能研究?

    0

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    2021-03-15 wxl882001

    了解

    0

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