Circulation:长期暴露于空气污染明显增加心血管和呼吸系统疾病风险

2021-04-21 Nebula MedSci原创

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既往评估空气污染暴露对非致命健康后果的影响的研究受到所研究污染物的数量的限制,而且多评估的是短期暴露。关于空气污染对非致命健康影响的最新研究已将其重点从短期暴露转移到了长期暴露。长期暴露研究的估计效果往往大于短期暴露的研究。

近日,发表在《循环》“Circulation”上的一篇最新研究“Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model”报告了空气污染与住院治疗的长期相关性。

在该研究中,Mahdieh等人在美国有医疗保险的人群中研究了长期暴露于<PM2.5微粒、NO2和对流层臭氧与因4种血管和呼吸疾病(心肌梗死、缺血性卒中、房颤/房扑和肺炎)住院的相关性。研究人员采用双重稳健的方法进行统计分析,该方法既依赖于逆概率加权,也依赖于结果模型中的调整来解决混淆问题。此外,研究人员还进一步研究了在较低污染物浓度下的这种相关性。

主要和次要预后结果分析

分析结果显示:长期暴露于PM2.5会增加本次所评估的所有预后结果的风险,其中卒中的风险增加最高,PM2.5浓度每增加1-ug/m3,卒中风险增加0.0091%(95% CI 0.0086-0.0097)。每年转化为2536位因缺血性卒中入院的患者,这可归因于研究人群的细颗粒物暴露水平增加了1个单位。

NO2暴露与因卒中(0.00059%/ppb,95% CI 0.00039-0.00075)和房颤(0.00129%/ppb,95% CI 0.00114-0.00148)入院的风险增加相关。对流层臭氧暴露与因肺炎入院的风险增加相关(0.00413%,95% CI 0.00376-0.00447)。

空气污染暴露水平对预后的影响

即使在较低的浓度下,所有污染物仍均与本研究所评估的结局风险不断增加相关。

总之,长期暴露于空气污染可对普通人的心血管和呼吸系统健康构成重大风险,即使空气污染水平较低

原始出处

Mahdieh Danesh Yazdi, et al. Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model. Circulation. 2021;143:1584–1596

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    2021-04-21 Amorewanyu

    很有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1419024, encodeId=d3591419024c4, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Fri Apr 23 02:05:45 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472721, encodeId=936514e2721b2, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Apr 23 02:05:45 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473272, encodeId=f86814e327253, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Apr 23 02:05:45 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959050, encodeId=ab3295905081, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210421/0e855fee2bfa4d728371049b021435b0/d6003e02326945edb52d30cd499ac917.jpg, createdBy=f47c5383362, createdName=Amorewanyu, createdTime=Wed Apr 21 14:21:12 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959038, encodeId=18e195903872, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Wed Apr 21 13:51:35 CST 2021, time=2021-04-21, status=1, ipAttribution=)]
    2021-04-21 梅斯小助手

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

    0

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