Lancet:COVID-19导致的全球抑郁症和焦虑症的流行率和负担分析

2021-11-06 MedSci原创 MedSci原创

精神障碍是造成全球健康相关负担的主要原因,其中抑郁症和焦虑症是造成这一负担的主要因素。

精神障碍是造成全球健康相关负担的主要原因,其中抑郁症和焦虑症是造成这一负担的主要因素。COVID-19大流行病的出现创造了一个环境,使不良心理健康的许多决定因素变得更加严重。

当务之急是需要关于COVID-19对心理健康影响的最新信息,以便为卫生系统的反应提供参考。最近一项研究中,国际COVID-19心理健康协作组织旨在量化COVID-19大流行病对2020年全球主要抑郁症和焦虑症的流行率和负担的影响。结果发表在Lancet杂志上。

研究人员对2020年1月1日-2021年1月29日期间发表的报告COVID-19大流行期间主要抑郁症和焦虑症患病率的数据进行了系统回顾。搜索了PubMed、Google Scholar,随后将收集到的数据用于元回归,通过COVID-19的影响指标(人员流动、每日SARS-CoV-2感染率和每日超额死亡率)估计大流行前和大流行中期(使用每个研究定义的时期)的主要抑郁症和焦虑症的流行率变化。然后用这个模型来估计按年龄、性别和地点的变化大流行前的流行率。使用最终的患病率估计值和残疾权重来估计主要抑郁症和焦虑症的残疾生活年数和残疾调整生命年数(DALYs)。

最终确定了5683个独特的数据源,其中48个符合纳入标准(46个研究符合主要抑郁症的标准,27个符合焦虑症的标准)。两项COVID-19影响指标,特别是每日SARS-CoV-2感染率和人员流动的减少,与严重抑郁症患病率的增加有关(B=0.9[95%CI: 0.1-1.8,每日SARS-CoV-2感染为18.1[7.9-28.3])和焦虑症(0.9[0.1-1.7]和13.8[10.7-17.0])。

同时,女性比男性受大流行病的影响更大、年轻群体比老年群体受影响更大。研究人员估计,在2020年受大流行病打击最严重的地区,根据人类流动性减少和每日SARS-CoV-2感染率来衡量,抑郁症和焦虑症的患病率增加最多。

COVID-19大流行前和流行中精神障碍的流行率

由于COVID-19大流行,全球将增加5300万例重度抑郁症患者(增加27.6%),全球焦虑症病例增加了76-200万(增加了25.6%)。总的来说,2020年,主要抑郁症在全球造成494万DALYs,焦虑症造成445万DALYs。

综上,COVID-19大流行病使大多数国家更加迫切地需要加强心理健康系统。

 

参考文献:

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. https://doi.org/10.1016/S0140-6736(21)02143-7

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    2022-05-06 howi
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    2022-10-07 lixiaol
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    2021-11-07 我思故我在2

    又学到了新知识

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    2021-11-07 学医无涯

    学习一下

    0

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    2021-11-07 ms9000001258055198

    学习了

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    2021-11-06 121bb8d4m13暂无昵称

    学习

    0

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焦虑症是常见的心理健康问题,通常发生在生命早期,包括童年、青春期或成年早期。研究人员发现,焦虑症影响着世界上大约10%的人口,且女性患病率是男性的2倍。

JAMA Psychiatry: 有氧运动或艾司西酞普兰治疗冠心病焦虑患者

艾司西酞普兰对患有冠心病的焦虑患者是安全有效的,同时有氧运动对改善冠心病患者焦虑有益

Complement Ther Med:饮用薰衣草花草茶可以减少老年人的抑郁和焦虑

世界各地老年人抑郁症和焦虑症的发病率逐渐上升。有学者认为薰衣草可以稳定人们的情绪,为验证此观点,研究人员进行了一项单盲临床试验,旨在评估薰衣草对老年人的焦虑和抑郁的影响,研究结果已发表于Complem

Acta Psychiatrica Scandinavica:代谢组学谱可用于区分焦虑症和抑郁症

炎症和动脉粥样硬化代谢组谱可能与抑郁的存在唯一相关,而与焦虑无关。代谢组特征可能是这些高度相关但又不相同的情绪状态的一个显著特征。

JAMA Psychiatry:当心!冠心病患者可能得了“双心病”!

艾司西酞普兰治疗焦虑对减少冠心病患者的焦虑是安全和有效的。

拓展阅读

Mol Psychiatry:成人抑郁症患者的压力生活事件模式和五种精神障碍和神经质的多基因评分

这篇文章在遗传上证明了压力源和素质是相互依存的,并且挑战基于生活事件的诊断和亚型(例如,反应性/内源性)。

Mol Psychiatry:星形胶质细胞与健康和精神障碍的相关性

作者收集了关于出生后早期大脑发育关键时期星形发生和星形胶质细胞介导的神经元网络重塑调节的最新进展,重点是突触消除。然后提出了替代假设,认为这些过程中的异常参与了 ND 和 NP 疾病的发生。

Mol Psychiatry :SUPER-Finland 研究中遗传因素对精神障碍病程严重程度和进展的影响

低 EA-PGS 的负面影响部分是通过物质使用障碍介导的,物质使用障碍是住院的主要危险因素。总之,作者表明高 SZ-PGS 和低 EA-PGS 均对精神病病程发展产生负面影响,但导致不同的病程轨迹。

J Affect Disord:通过孟德尔随机化分析探索系统性红斑狼疮与精神障碍风险的关联

本项基于两样本的孟德尔随机化分析为SLE可能增加广泛性焦虑障碍和精神分裂症风险提供了证据。

Int. J. Ment. Health Addiction:出院后基于电话的戒烟干预对严重精神健康障碍患者的有效性

这项研究证明了通过现有的区域戒烟热线提供的主动的、基于激励性的电话干预的有效性。该干预措施旨在帮助最近从急性精神病住院治疗中出院的患有精神健康和药物滥用障碍的无动机吸烟者。

Psychol. Med.:使用家族遗传风险评分预测不同精神障碍的相互影响

一种精神或物质使用障碍的发生通常对后续疾病的风险有因果关系。这种机制可能在很大程度上导致了精神疾病中普遍存在的合并症。