Clinica Chimica Acta:多中心研究评价高灵敏度cTnI方法第99百分位数及参考值的变化

2019-08-08 gladiator MedSci原创

意大利临床生物化学学会<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso-bidi-font-family:&quot;Times New

意大利临床生物化学学会(SIBioC)和欧洲配体分析学会(ELAS)意大利分会最近推进了一项多中心研究(意大利hs-cTnI研究),目的是评估意大利市场上最流行的cTnI方法的分析性能和参考价值。本文的目的是报告意大利hs-cTnI关于访问cTnI方法的第99个百分位URL和第99URL参考变化(RCV)值评估的研究结果。

研究结果显示,8个意大利临床中心共收集了1306名健康成人志愿者的肝素血浆样本。其中,每个中心收集了50150个健康成人的血浆样本。所有志愿者均否认存在慢性或急性疾病,且常规实验室检测值(包括肌酐、电解质、葡萄糖和血细胞计数)均正常。457名成年受试者(平均年龄63.0; SD 8.1岁,最小47岁,最大86岁)的老年队列也进行了ECG和心脏成像分析,以排除无症状心脏病的存在。

本研究结果证实,使用DxI平台的Access hsTnI方法符合国际cTn检测高灵敏度方法指南要求的两个标准。此外,本研究的结果证实,第99百分位URL值的计算不仅受参考群体年龄和性别的影响较大,而且受计算cTnI分布参数的统计方法的影响也较大。

原始出处:

Aldo ClericoAndrea RipoliEvaluation of 99th percentile and reference change values of a high-sensitivity cTnI method: A multicenter study

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    2019-11-15 shanyongle
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    2020-03-30 windight
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    2020-03-05 respect
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    2019-08-10 huagfeg

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