治疗糖尿病,不要忘记使用他汀

2016-06-20 郭艺芳心前沿 郭艺芳心前沿

对于糖尿病患者,不应仅仅关注降糖。动脉粥样硬化性心血管疾病(如冠心病、心肌梗死与脑梗死等)是糖尿病患者致死致残的主要原因,有效防治大血管病变才是治疗糖尿病的最终目标。为达此目的,一方面要合理的控制血糖,同时要积极控制血压并根据患者具体情况应用他汀降低胆固醇水平。哪些糖尿病患者需要接受他汀治疗?所有确诊动脉粥样硬化性心血管疾病(冠心病、缺血性卒中、外周动脉疾病[如预动脉或下肢动脉狭窄超过50%]等)

对于糖尿病患者,不应仅仅关注降糖。动脉粥样硬化性心血管疾病(如冠心病、心肌梗死与脑梗死等)是糖尿病患者致死致残的主要原因,有效防治大血管病变才是治疗糖尿病的最终目标。为达此目的,一方面要合理的控制血糖,同时要积极控制血压并根据患者具体情况应用他汀降低胆固醇水平。


哪些糖尿病患者需要接受他汀治疗?


所有确诊动脉粥样硬化性心血管疾病(冠心病、缺血性卒中、外周动脉疾病[如预动脉或下肢动脉狭窄超过50%]等)的患者,无论其胆固醇是否增高,均应长期应用他汀治疗,并将低密度脂蛋白胆固醇(LDL-C)降低至<1.8mmol/L;


未合并心血管病者,首先要根据其否存在其他心血管危险因素确定LDL-C的目标值,若患者LDL-C水平超过此目标值则应予以他汀治疗。不同糖尿病患者的LDL-C目标值如下:


1)合并至少一项其他危险因素(男≥45岁,女≥55,高血压,吸烟,HDL-C<1.04mmo/L,体质指数≥28Kg/m2,早发缺血性心血管病家族史),LDL-C目标值<1.8mmo/L;


2)不伴其他危险因素,LDL-C目标值<2.6mmo/L。


特别强调


糖尿病患者最常见的血脂紊乱是甘油三酯增高或高密度脂蛋白胆固醇降低,但这并不意味着应该应用贝特类或烟酸类药物对此进行干预。如果甘油三酯严重增高(≥5.6 mmol/L)可首选贝特治疗。其他患者均应将他汀作为首选的降脂药,降低胆固醇水平是最重要的治疗目标。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=132108, encodeId=0a27132108f7, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:26:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125791, encodeId=1edf125e9183, content=感谢分享,临床上很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 22:30:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91412, encodeId=ca0b91412e8, content=期待后续报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jun 28 08:23:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91337, encodeId=61f99133eb6, content=他丁类药物真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 16:24:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91068, encodeId=0c3791068a0, content=降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Sat Jun 25 03:39:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=132108, encodeId=0a27132108f7, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:26:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125791, encodeId=1edf125e9183, content=感谢分享,临床上很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 22:30:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91412, encodeId=ca0b91412e8, content=期待后续报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jun 28 08:23:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91337, encodeId=61f99133eb6, content=他丁类药物真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 16:24:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91068, encodeId=0c3791068a0, content=降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Sat Jun 25 03:39:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    感谢分享,临床上很实用

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=132108, encodeId=0a27132108f7, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:26:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125791, encodeId=1edf125e9183, content=感谢分享,临床上很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 22:30:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91412, encodeId=ca0b91412e8, content=期待后续报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jun 28 08:23:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91337, encodeId=61f99133eb6, content=他丁类药物真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 16:24:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91068, encodeId=0c3791068a0, content=降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Sat Jun 25 03:39:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-28 I come

    期待后续报道

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=132108, encodeId=0a27132108f7, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:26:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125791, encodeId=1edf125e9183, content=感谢分享,临床上很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 22:30:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91412, encodeId=ca0b91412e8, content=期待后续报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jun 28 08:23:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91337, encodeId=61f99133eb6, content=他丁类药物真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 16:24:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91068, encodeId=0c3791068a0, content=降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Sat Jun 25 03:39:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-27 oo902

    他丁类药物真的很重要

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=132108, encodeId=0a27132108f7, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:26:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125791, encodeId=1edf125e9183, content=感谢分享,临床上很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 22:30:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91412, encodeId=ca0b91412e8, content=期待后续报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jun 28 08:23:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91337, encodeId=61f99133eb6, content=他丁类药物真的很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Mon Jun 27 16:24:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91068, encodeId=0c3791068a0, content=降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfb791835, createdName=CHBLY, createdTime=Sat Jun 25 03:39:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-06-25 CHBLY

    降脂的他丁药是跟降糖药一起终生吃吗?怕吃久了对肝功能有影响

    0

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