Ann Transl Med:不同浓度人脐带间充质干细胞改善BALB/c小鼠银屑病样皮损的效果

2022-05-14 医路坦克 MedSci原创

银屑病是一种免疫介导的慢性、复发性炎症性皮肤病,鉴于干细胞与银屑病发病机制关系的研究,干细胞可能是系统性治疗银屑病的新突破,本文就hUC-MSCs(人脐带间充质干细胞)对小鼠银屑病模型的相关作用。

银屑病是一种免疫介导的慢性、复发性炎症性皮肤病,其典型临床表现为鳞状红斑或斑块,可以是局部的或广泛分布的。银屑病的病因涉及遗传、免疫、环境等因素。银屑病通过主要由T淋巴细胞介导并由多种免疫细胞共同参与的免疫反应导致滑膜细胞和软骨细胞的过度角质化细胞增殖或炎症。

鉴于干细胞与银屑病发病机制关系的研究,干细胞可能是系统性治疗银屑病的新突破。然而,在观察其治疗效果的同时,有必要研究干细胞在银屑病治疗中的有效浓度。我们在体外研究了人骨髓间充质干细胞延缓小鼠银屑病皮损的疗效和有效浓度。由于细胞因子水平的变化可以间接反映皮损的变化趋势,因此选择了干扰素(IFN)-γ、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-17和IL-12四种细胞因子来反映干细胞治疗的效果。我们发现hUC-MSCs(人脐带间充质干细胞)通过抑制IL-23和IL-17因子的浓度对咪喹莫特诱导的小鼠银屑病具有治疗作用,有可能成为银屑病临床治疗的一种新的治疗途径。

建立咪喹莫特诱导的BALB/c小鼠银屑病样模型,将动物随机分为对照组、模型组、不同浓度人脐带间充质干细胞组(分别经尾静脉注射脐带干细胞1×107/kg、2×107/kg、4×107/kg)和新鲜人脐带间充质干细胞组(经尾静脉注射新鲜脐带干细胞2×107/kg)。银屑病面积和严重程度指数(PASI)评分用于观察皮损的变化。he染色观察表皮厚度、角质化程度和炎性细胞浸润情况。用酶联免疫吸附法(ELISA)测定小鼠血清和皮肤中TNF-α、IFN-γ、IL-17A、IL-23等细胞因子的浓度。

与对照组相比,用hUC-MSCs治疗的小鼠表现出良好的剂量反应依赖性。随着hUC-MSCs浓度的增加,脾脏指数也增加。根据PASI积分趋势图,hUC-MSCs可以延缓皮损的出现,加速皮损的恢复。HE染色显示hUC-MSCs治疗组的角化不全细胞数量明显减少,真皮增生和红细胞外渗炎性细胞浸润程度明显低于模型组。hUC-MSCs浓度越高,血清和皮肤组织中四种细胞因子的浓度越低。

hUC-MSCs对咪喹莫特诱导的小鼠银屑病有明显的治疗作用,高浓度的hUC-MSCs治疗效果最好。这种作用强度是剂量依赖性的,高浓度的hUC-MSCs具有更好的治疗效果。

文献来源:Lin Y,  Wang H,  Jiang C,Effects of different concentrations of human umbilical cord mesenchymal stem cells to ameliorate psoriasis-like skin lesions in BALB/c mice.Ann Transl Med 2022 Jan;10(2)

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createdName=病毒猎手, createdTime=Mon May 09 11:09:38 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Fri Jul 08 18:48:16 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657640, encodeId=2cf3165e6404d, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Fri Dec 02 06:17:49 CST 2022, time=2022-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1219563, encodeId=e1ec121956318, content=好文章,谢谢分享。, beContent=null, objectType=article, 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createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 10 10:17:49 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218055, encodeId=b0061218055f4, content=<a href='/topic/show?id=d8229e2323c' target=_blank style='color:#2F92EE;'>#间充质干细胞#</a>对<a href='/topic/show?id=e6488633e2c' target=_blank style='color:#2F92EE;'>#自身免疫性疾病#</a>效果应该是不错的,包括<a href='/topic/show?id=d4d196630b4' target=_blank style='color:#2F92EE;'>#银屑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97232, encryptionId=d8229e2323c, topicName=间充质干细胞), TopicDto(id=86337, encryptionId=e6488633e2c, topicName=自身免疫性疾病), TopicDto(id=96630, encryptionId=d4d196630b4, topicName=银屑病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Mon May 09 11:09:38 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-07-08 屋顶瞄爱赏月

    签到学习

    0

  5. 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createdName=病毒猎手, createdTime=Mon May 09 11:09:38 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-12-02 bsmagic9140
  6. 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createdName=病毒猎手, createdTime=Mon May 09 11:09:38 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-05-14 yangchou

    好文章,谢谢分享。

    0

  7. 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    2022-05-09 病毒猎手

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