Gynecol Endocrinol:来曲唑可通过改善子宫内膜接受能力提高PCOS患者的妊娠率

2020-10-01 MedSci原创 MedSci原创

该研究旨在比较枸橼酸氯米芬(CC)和来曲唑对多囊卵巢综合征(PCOS)女性子宫内膜接受排卵诱导的影响。

该研究旨在比较枸橼酸氯米芬(CC)和来曲唑对多囊卵巢综合征(PCOS)女性子宫内膜接受排卵诱导的影响,研究结果已在线发表于。

一项随机对照研究纳入了160名被诊断为PCOS的患者,其中80名患者接受50mg的CC,80名患者接受2.5mg的来曲唑以成功诱导排卵。测量子宫内膜厚度和形态、子宫动脉和子宫内膜下区的血流、子宫内膜体积和血管化指数。

 

结果显示,来曲唑组子宫内膜多层形态比例在人绒毛膜促性腺激素(hCG)给药当天较CC组明显增加(77.5% vs. 55.0%)。来曲唑组给药当日及排卵后7-9天子宫内膜的体积、血管化指数(VI)、流量指数(FI)均明显增加。来曲唑组生化妊娠率、临床妊娠率、持续妊娠率均较CC组显著提高(分别为36.3%、30.0%、22.5% vs 21.3%、13.8%、10.0%)。

 

综上所述,该研究结果表明,与CC相比,来曲唑通过改善子宫内膜接受能力提高了PCOS患者的妊娠率。

 

原始出处:

 

Li WangXinqiang Wen, et al., Comparison of endometrial receptivity of clomiphene citrate versus letrozole in women with polycystic ovary syndrome: a randomized controlled study. Gynecol Endocrinol. 2019 Oct;35(10):862-865. doi: 10.1080/09513590.2019.1612358. 

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