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JAMA Neurol：阿托伐他汀用于慢性硬膜下血肿的治疗

2018-08-02 zhangfan MedSci原创

慢性硬膜下血肿cSDH阿托伐他汀
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研究认为阿托伐他汀是安全有效的非手术慢性硬膜下血肿治疗手段

慢性硬膜下血肿(CSDH)是老年人常见的创伤相关并发症，手术是其首选治疗方法。近日研究人员考察了阿托伐他汀作为非手术手段对减少血肿，改善CSDH患者临床预后的效果。

ATOCH研究为随机双盲安慰剂对照研究在中国开展，196名CT确诊的CSDH患者参与，随机接受20mg阿托伐他汀或安慰剂，持续8周，随访16周。研究的主要终点为治疗8周后CT血肿体积（HV）改变，次要结果为第4、12和24周HV和神经功能变化。

参与者平均年龄63.6岁，男性占86.2%，组间基线HV以及临床特征相近，每组98人。8周后，阿托伐他汀组患者HV减少12.55mL，显著优于安慰剂组。45名(45.9%)阿托伐他汀组患者神经功能得到显著改善，而安慰剂组仅28人(28.6%)，阿托伐他汀治疗后临床改善的比值比为1.957。11名服用阿托伐他汀的患者(11.2%)和23名服用安慰剂的患者(23.5%)在试验期间因血肿扩大和(或)临床状况恶化而接受手术治疗，未发生严重的不良事件。

研究认为阿托伐他汀是安全有效的非手术慢性硬膜下血肿治疗手段。

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    2019-02-04 wodejia-dayu

    #慢性硬膜下血肿#

    0

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    2018-09-25 12498710m11暂无昵称

    #硬膜下#

    0

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    2019-04-14 yinhl1978

    #Neurol#

    0

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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-13 1e135751m36(暂无匿称)

    那需要吃好久呢？

    0

  5. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-07 121d6937m04(暂无昵称)

    学到了！

    0

  6. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-03 654699882_84926986

    #血肿#

    0

  7. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-03 lizhou0205

    #硬膜下血肿#

    0

  8. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-02 汪海波

    谢谢分享

    0

  9. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-02 Y—xianghai

    学习了长知识

    0

  10. 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channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 02 09:02:56 CST 2018, time=2018-08-02, status=1, ipAttribution=)]
    2018-08-02 Y—xianghai

    学习了长知识

    0

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