Alzheimers & Dementia:脑震荡会让人变傻?——橄榄球运动员脑震荡与长期认知功能的研究

2021-11-04 Naomii MedSci原创

近日,有研究人员评估了退役橄榄球运动员自我报告的脑震荡与认知功能之间的关系。脑震荡和认知功能之间没有关联;然而,与年龄的显著交互作用显示,在老年参与者中存在关联。

      自从慢性创伤性脑病(CTE)首次被描述为一种病因学实体以来,研究者们的注意力集中在与运动相关的轻度创伤性脑损伤或脑震荡的长期后遗症上。已有3例提示CTE的神经病理变化被报道在拳击手、美式橄榄球运动员、冰球运动员、足球运动员和橄榄球运动员。然而,这些报道大多基于病例报道,样本量有限。在美国足球运动员中的研究结果还表明,职业生涯的长短与更严重的神经病理有关,这表明头部亚震荡可能起到了作用。对目前流行病学证据的审查表明,以前患有脑震荡的运动员认知功能低下的风险增加,但研究结果并不一致。相反,体育活动和参与体育运动对健康的益处,包括对认知功能下降的保护作用,是确凿无疑的。目前尚不清楚的是,体育运动的益处在多大程度上弥补脑震荡的任何潜在有害影响,以及这种危害是否是运动特有的。

      在橄榄球联盟球员中,目前几乎没有证据表明脑震荡对认知的长期影响。一项研究发现脑震荡与认知功能低下之间存在关联,但效果甚微,而且有多种比较。相反,另一项研究没有发现同样的关联,可能是因为缺乏检测微小影响的能力。第三项研究发现没有关联,尽管与其他非接触性运动员相比,轻度认知障碍在橄榄球运动员中更常见。因此,退役橄榄球联盟球员的大脑健康和健康老龄化研究的目的是评估退役精英橄榄球运动员脑震荡和认知功能之间的长期联系。

      近日,有研究人员评估了退役橄榄球运动员自我报告的脑震荡与认知功能之间的关系。

      研究招募了前英格兰优秀男子橄榄球联盟球员(年龄在50岁以上)。使用Brain-Q工具收集橄榄球相关脑震荡的暴露情况。主要的结果衡量标准是临床前阿尔茨海默病认知复合量表(PACC)。对脑震荡和PACC评分之间的关系进行线性回归,调整混杂因素。

  • 共招募146名受试者,其职业生涯平均(标准差)为15.8(5.4)年。
  • 共有79.5%的人报告与橄榄球有关脑震荡。
  • 未发现脑震荡与PACC相关(β-0.03[95%可信区间:-1.31,0.26])。
  • 80岁以上报告3+脑震荡的参与者的认知功能比没有脑震荡的人差(β-1.04[95%CI:-1.62,-0.47])。

     总体而言,脑震荡和认知功能之间没有关联;然而,与年龄的显著交互作用显示,在老年参与者中存在关联。

文献来源:https://pubmed.80599.net/34668650/

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    2022-04-10 anminleiryan
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    2021-11-05 TZF0804
  5. [GetPortalCommentsPageByObjectIdResponse(id=1779807, encodeId=6abb1e798071d, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jan 14 23:58:33 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878429, encodeId=e6d518e842963, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sun Apr 10 03:58:33 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718085, encodeId=437e1e180851e, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Wed Aug 10 16:58:33 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316278, encodeId=371a13162e83f, content=<a href='/topic/show?id=654a85168c0' target=_blank style='color:#2F92EE;'>#脑震荡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85168, encryptionId=654a85168c0, topicName=脑震荡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338526, encodeId=69ab1338526bc, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604612, encodeId=cc0c160461292, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066970, encodeId=971510669e0a5, content=有意思!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211030/727082c36c794e7a9cc18aad6a2886d1/d8e51d61f5f74b299541d33450410b09.jpg, createdBy=26f72982264, createdName=海阔天空Sin, createdTime=Thu Nov 04 16:28:25 CST 2021, time=2021-11-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1779807, encodeId=6abb1e798071d, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jan 14 23:58:33 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878429, encodeId=e6d518e842963, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sun Apr 10 03:58:33 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718085, encodeId=437e1e180851e, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Wed Aug 10 16:58:33 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316278, encodeId=371a13162e83f, content=<a href='/topic/show?id=654a85168c0' target=_blank style='color:#2F92EE;'>#脑震荡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85168, encryptionId=654a85168c0, topicName=脑震荡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338526, encodeId=69ab1338526bc, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604612, encodeId=cc0c160461292, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066970, encodeId=971510669e0a5, content=有意思!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211030/727082c36c794e7a9cc18aad6a2886d1/d8e51d61f5f74b299541d33450410b09.jpg, createdBy=26f72982264, createdName=海阔天空Sin, createdTime=Thu Nov 04 16:28:25 CST 2021, time=2021-11-04, status=1, ipAttribution=)]
    2021-11-05 gujh
  7. [GetPortalCommentsPageByObjectIdResponse(id=1779807, encodeId=6abb1e798071d, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Fri Jan 14 23:58:33 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878429, encodeId=e6d518e842963, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Sun Apr 10 03:58:33 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718085, encodeId=437e1e180851e, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Wed Aug 10 16:58:33 CST 2022, time=2022-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316278, encodeId=371a13162e83f, content=<a href='/topic/show?id=654a85168c0' target=_blank style='color:#2F92EE;'>#脑震荡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85168, encryptionId=654a85168c0, topicName=脑震荡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338526, encodeId=69ab1338526bc, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604612, encodeId=cc0c160461292, content=<a href='/topic/show?id=88e6941544c' target=_blank style='color:#2F92EE;'>#运动员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94154, encryptionId=88e6941544c, topicName=运动员)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c1419230799, createdName=gujh, createdTime=Fri Nov 05 09:58:33 CST 2021, time=2021-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066970, encodeId=971510669e0a5, content=有意思!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211030/727082c36c794e7a9cc18aad6a2886d1/d8e51d61f5f74b299541d33450410b09.jpg, createdBy=26f72982264, createdName=海阔天空Sin, createdTime=Thu Nov 04 16:28:25 CST 2021, time=2021-11-04, status=1, ipAttribution=)]
    2021-11-04 海阔天空Sin

    有意思!

    0

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