Behavioural Brain Research :额中线θ频率和概率学习—经颅交流电刺激研究

2020-07-22 MedSci原创 MedSci原创

概率学习是一种基本的认知能力,它提取并代表我们环境的规律性,从而在感知和获得知觉,运动,认知和社交技能的过程中进行预测性处理。

 与执行功能/工作记忆相关的神经网络与概率学习之间存在竞争。在相关研究中,θ同步与前者相关联,而与后者不同步。作者的目的是测试无创经颅交流电(tACS)刺激额顶顶中线θ同步与概率学习之间的因果关系。作者假设theta同步通过调节竞争关系来破坏概率学习性能。

方法:二十六名年轻人执行了交替序列反应时间(ASRT)任务,以相隔一周时间的两次会议评估概率学习。刺激采用双盲交叉受试者内部设计,参与者之间采用平衡的主动theta tACS和假刺激进行刺激。在整个任务中(大约20分钟),对正弦电流施加1 mA的峰峰强度,以进行主动刺激,假刺激则以30 s的速率进行。比较主动和假刺激时的表现,我们没有发现额顶顶中线theta tACS对概率学习的影响。主要研究者和参与者都没有意识到当前的刺激状况。 不参与与参与者互动的第二个研究者仅负责设置刺激。 刺激与概率学习任务(交替序列反应时间,ASRT任务)同时进行。

结果:作者的研究是第一个将tACS应用于影响概率学习的研究。 没有发现统计学上显着的影响额叶正中线theta tACS(〜0.1 V / m电场强度)对主动和假刺激行为的概率学习的影响。 

原文链接:Zavecz, Z., et al., Frontal-midline theta frequency and probabilistic learning: A transcranial alternating current stimulation study. Behavioural Brain Research, 2020. 393: p. 112733.https://doi.org/10.1016/j.bbr.2020.112733

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    2020-07-24 仁医06
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    2020-07-24 yangshch

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