Diabetes Care:血清淀粉样蛋白A或预测2型糖尿病

2012-12-19 Diabetes Care Diabetes Care

  德国研究者一项研究表明,急性期血清淀粉样蛋白A(A-SAA)和高敏C反应蛋白(hs-CRP)对2型糖尿病有相似的预测关系。该研究12月13日在线发表于《糖尿病护理》(Diabetes Care)杂志。   为了研究S-SAA水平是否在2型糖尿病发生前已升高且独立于其他危险因素包括葡萄糖代谢参数,研究者在奥格斯堡地区基于人群的健康协作研究(KORA)S4试验中,在包含口服糖耐量检测的

  德国研究者一项研究表明,急性期血清淀粉样蛋白A(A-SAA)和高敏C反应蛋白(hs-CRP)对2型糖尿病有相似的预测关系。该研究12月13日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  为了研究S-SAA水平是否在2型糖尿病发生前已升高且独立于其他危险因素包括葡萄糖代谢参数,研究者在奥格斯堡地区基于人群的健康协作研究(KORA)S4试验中,在包含口服糖耐量检测的7年随访期间,监测了836名初始非糖尿病且无临床明显炎症的受试者的A-SAA浓度。

  结果表明,A-SAA浓度与2型糖尿病的发生显著相关,校正年龄和性别后A-SAA升高1个标准差的2型糖尿病风险比(OR)为1.28(95%CI为1.08~1.53,P=0.005),较年轻的受试者尤甚。校正糖代谢参数后上述相关性减弱,OR为1.16,P=0.15。对hs-CRP的分析结果相似,OR分别为1.39(P=0.0006)和1.13(P=0.34)。不过,即使校正糖代谢参数,随访的A-SAA浓度仍与2小时血糖水平显著相关(P=0.008)。

2型糖尿病相关的拓展阅读:


Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study

OBJECTIVE 

We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism.

RESEARCH DESIGN AND METHODS 

Within the population-based Cooperative Health Research in the Region of Augsburg (KORA) S4 study, we measured A-SAA concentrations in 836 initially nondiabetic subjects (55–74 years of age) without clinically overt inflammation who participated in a 7-year follow-up examination including an oral glucose tolerance test.

RESULTS 

A-SAA concentrations were significantly associated with incident type 2 diabetes (odds ratio [OR] for a one-SD increase of A-SAA adjusted for age and sex = 1.28 [95% CI 1.08–1.53], P = 0.005), particularly in younger subjects (P value for interaction = 0.047). The association attenuated when adjusting for parameters of glucose metabolism (fasting glucose, fasting insulin, HbA1c, and 2-h glucose; OR 1.16 [0.95–1.42], P = 0.15). Similar analyses for high-sensitive C-reactive protein (hs-CRP) yielded the following ORs: 1.39 (1.10–1.68, P = 0.0006) and 1.13 (0.88–1.45, P = 0.34), respectively. In contrast, A-SAA concentrations were significantly associated with 2-h glucose levels at follow-up even after adjustment for parameters of glucose metabolism (P = 0.008, n = 803).

CONCLUSIONS 

Our findings indicate similarly strong prospective associations with type 2 diabetes for A-SAA and hs-CRP and suggest a potential causal link via postchallenge hyperglycemia.



    



版权声明:
本网站所有注明“来源:梅斯医学”或“来源:MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明“来源:梅斯医学”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言

相关资讯

血清淀粉样蛋白A(SAA)示肾癌晚期

     德国一项研究表明,晚期肾癌患者常伴急性时相反应蛋白,如C反应蛋白(CRP)和血清淀粉样蛋白A(SAA)浓度升高;SAA识别晚期肾癌的敏感性高于CRP。研究论文近期发表于《抗癌研究》(Anticancer Research)杂志。   该研究纳入了48例局限性和67例晚期肾癌患者,并设24例对照患者。   研究在肾切除术前和术后第5天检测了患者的白介素6(IL-6)、CPR